Patrolling the nucleus: inner nuclear membrane-associated degradation. [PDF]
Curr Genet, 2019 Protein quality control and transport are important for the integrity of organelles such as the endoplasmic reticulum, but it is largely unknown how protein homeostasis is regulated at the nuclear envelope (NE) despite the connection between NE protein ...
Smoyer CJ, Jaspersen SL.
europepmc +5 more sources
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat. [PDF]
Dev Cell, 2021 Summary The cell nucleus is surrounded by a double membrane. The lipid packing and viscosity of membranes is critical for their function and is tightly controlled by lipid saturation. Circuits regulating the lipid saturation of the outer nuclear membrane
Romanauska A, Köhler A.
europepmc +4 more sources
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization. [PDF]
Dev Cell, 2019 Summary Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) composition ...
Barbosa AD +12 more
europepmc +6 more sources
Functional K(v)10.1 channels localize to the inner nuclear membrane. [PDF]
PLoS ONE, 2011 Ectopically expressed human K(V)10.1 channels are relevant players in tumor biology. However, their function as ion channels at the plasma membrane does not totally explain their crucial role in tumors.
Ye Chen +5 more
doaj +6 more sources
Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane [PDF]
Nature CommunicationsThe nuclear envelope is a specialized subdomain of the endoplasmic reticulum and comprises the inner and outer nuclear membranes. Despite the crucial role of the inner nuclear membrane in genome regulation, its lipid metabolism remains poorly understood.
Anete Romanauska +3 more
doaj +2 more sources
Rice small protein OsS1Fa1 participates in stress responses as an inner nuclear membrane protein [PDF]
Plant Signaling & BehaviorThe rice small protein OsS1Fa1, a homolog of spinach S1Fa, plays a significant role in drought tolerance, attributed to its transmembrane domain. In this study, we aim to further elucidate the potential roles of OsS1Fa1 in cold and biotic stresses as an ...
Wang Ki Min +3 more
doaj +2 more sources
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants. [PDF]
Nat Commun, 2020 The inner nuclear membrane (INM) selectively accumulates proteins that are essential for nuclear functions; however, overaccumulation of INM proteins results in a range of rare genetic disorders. So far, little is known about how defective, mislocalized,
Huang A +7 more
europepmc +2 more sources
eLife, 2017 Newly synthesized membrane proteins are targeted to the inner nuclear membrane (INM) by diffusion within the membrane system of the endoplasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear partners. Using a
Sumit Pawar +4 more
doaj +2 more sources
A distinct inner nuclear membrane proteome in Saccharomyces cerevisiae gametes [PDF]
G3: Genes, Genomes, Genetics, 2021 The inner nuclear membrane (INM) proteome regulates gene expression, chromatin organization, and nuclear transport; however, it is poorly understood how changes in INM protein composition contribute to developmentally regulated processes, such as ...
Shary N Shelton +3 more
doaj +2 more sources
The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. [PDF]
PLoS Biology, 2022 Nuclear envelope membrane proteins (NEMPs) are a conserved family of nuclear envelope (NE) proteins that reside within the inner nuclear membrane (INM). Even though Nemp1 knockout (KO) mice are overtly normal, they display a pronounced splenomegaly. This
Didier Hodzic +8 more
doaj +2 more sources