Results 21 to 30 of about 307,971 (276)

Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane. [PDF]

Int J Mol Sci, 2019
LRRC59 (leucine-rich repeat-containing protein 59) is a tail-anchored protein with a single transmembrane domain close to its C-terminal end that localizes to the endoplasmic reticulum (ER) and the nuclear envelope. Here, we investigate the mechanisms of
Blenski M, Kehlenbach RH.
europepmc   +2 more sources

Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. [PDF]

Elife, 2019
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M.   +4 more
europepmc   +2 more sources

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane. [PDF]

Nat Commun, 2019
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.
Fontana GA, Hess D, Reinert JK, Mattarocci S, Falquet B, Klein D, Shore D, Thomä NH, Rass U.   +8 more
europepmc   +2 more sources

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]

eLife
The inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella, Regan F Volk, Balyn W Zaro, Abigail Buchwalter   +3 more
doaj   +2 more sources

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Cell Reports, 2015
Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway.
Tzviya Zeev-Ben-Mordehai, Marion Weberruß, Michael Lorenz, Juliana Cheleski, Teresa Hellberg, Cathy Whittle, Kamel El Omari, Daven Vasishtan, Kyle C. Dent, Karl Harlos, Kati Franzke, Christoph Hagen, Barbara G. Klupp, Wolfram Antonin, Thomas C. Mettenleiter, Kay Grünewald   +15 more
doaj   +2 more sources

Dissecting the telomere-inner nuclear membrane interface formed in meiosis [PDF]

Nature Structural & Molecular Biology, 2017
Tethering telomeres to the inner nuclear membrane (INM) allows homologous chromosome pairing during meiosis. The meiosis-specific protein TERB1 binds the telomeric protein TRF1 to establish telomere–INM connectivity and is essential for mouse fertility ...
D. Pendlebury, Y. Fujiwara, V. M. Tesmer, E. Smith, Hiroki Shibuya, Yoshinori Watanabe, J. Nandakumar   +6 more
semanticscholar   +3 more sources

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane [PDF]

Cell, 2015
Summary Vesicular nucleo-cytoplasmic transport is becoming recognized as a general cellular mechanism for translocation of large cargoes across the nuclear envelope.
C. Hagen, Kyle C. Dent, T. Zeev-Ben-Mordehai, M. Grange, J. Bosse, C. Whittle, B. Klupp, C. A. Siebert, D. Vasishtan, Felix J. B. Bäuerlein, J. Cheleski, S. Werner, P. Guttmann, S. Rehbein, K. Henzler, Justin Demmerle, B. Adler, U. Koszinowski, L. Schermelleh, G. Schneider, L. Enquist, J. Plitzko, T. Mettenleiter, K. Grünewald   +23 more
semanticscholar   +6 more sources

Inner Nuclear Membrane Protein Man1 [PDF]

Definitions, 2020

semanticscholar   +2 more sources

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

Frontiers in Cell and Developmental Biology, 2022
Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema, Merel Stiekema, Frederik Houben, Frederik Houben, Fons Verheyen, Marcel Borgers, Julia Menzel, Martin Meschkat, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Frans C. S. Ramaekers, Jos L. V. Broers, Jos L. V. Broers, Jos L. V. Broers   +16 more
doaj   +1 more source

Making and breaking the inner nuclear membrane proteome

Current Opinion in Cell Biology, 2022
The nuclear envelope (NE) is the defining feature of eukaryotic cells, separating the nucleus from the cytoplasm. It has a complex architecture consisting of two lipid bilayers that, despite being continuous between them and with the endoplasmic reticulum, have different protein compositions consistent with their distinct functions.
Hahn, Lilli, Carvalho, Pedro
openaire   +3 more sources