Results 31 to 40 of about 307,971 (276)

Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane [PDF]

Proceedings of the National Academy of Sciences, 2001
The nuclear envelope (NE) is one of the least characterized structures of eukaryotic cells. The study of its functional roles is hampered by the small number of proteins known to be specifically located to it. Here, we present a comprehensive characterization of the NE proteome.
M, Dreger, L, Bengtsson, T, Schöneberg, H, Otto, F, Hucho   +4 more
openaire   +2 more sources

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress. [PDF]

Current Opinion in Cell Biology, 2017
Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
M. Lye, Adrian R. Wilkie, D. Filman, J. Hogle, D. Coen   +4 more
semanticscholar   +3 more sources

Protein quality control at the inner nuclear membrane [PDF]

Nature, 2014
The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane is continuous with the endoplasmic reticulum and is the site of membrane protein synthesis ...
Anton Khmelinskii, E. Błaszczak, M. Pantazopoulou, Bernd Fischer, Deike J. Omnus, Gaëlle Le Dez, A. Brossard, Alexander Gunnarsson, J. Barry, M. Meurer, Daniel Kirrmaier, Charles Boone, W. Huber, Gwenaël Rabut, P. Ljungdahl, M. Knop   +15 more
semanticscholar   +4 more sources

Targeting and Insertion of Membrane Proteins in Mitochondria

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
doaj   +1 more source

The Inner Nuclear Membrane Takes On Lipid Metabolism [PDF]

Developmental Cell, 2018
Challenging the idea of the inner nuclear membrane (INM) being an inert compartment, recent work in S. cerevisiae shows that the INM can metabolize lipids and that local lipid metabolism can regulate transcription in response to lipid availability, suggesting a functional role for the INM in cellular lipid homeostasis.
Holly, Merta, Shirin, Bahmanyar
openaire   +2 more sources

The nuclear lamina is a hub for the nuclear function of Jacob

Molecular Brain, 2021
Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova   +4 more
doaj   +1 more source

The LEM-ESCRT toolkit: Repair and maintenance of the nucleus

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the ...
Sapan Borah, Karthigeyan Dhanasekaran, Santosh Kumar   +2 more
doaj   +1 more source

Genetic architecture of band neutrophil fraction in Iceland

Communications Biology, 2022
A GWAS in Iceland reveals that variants in inner nuclear membrane proteins are associated with nuclear morphology of granulocytes and band neutrophil fraction.
Gudjon R. Oskarsson, Magnus K. Magnusson, Asmundur Oddsson, Brynjar O. Jensson, Run Fridriksdottir, Gudny A. Arnadottir, Hildigunnur Katrinardottir, Solvi Rognvaldsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Erna V. Ivarsdottir, Lilja Stefansdottir, Egil Ferkingstad, Kristjan Norland, Vinicius Tragante, Jona Saemundsdottir, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Svanhvit Sigurjonsdottir, Karen O. Petursdottir, Olafur B. Davidsson, Thorunn Rafnar, Hilma Holm, Isleifur Olafsson, Pall T. Onundarson, Brynjar Vidarsson, Olof Sigurdardottir, Gisli Masson, Daniel F. Gudbjartsson, Ingileif Jonsdottir, Gudmundur L. Norddahl, Unnur Thorsteinsdottir, Patrick Sulem, Kari Stefansson   +33 more
doaj   +1 more source

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

eLife, 2016
Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai, Chenguang Zhao, Elizabeth Turner, Christian Schlieker   +3 more
doaj   +1 more source

The role of inner nuclear membrane protein emerin in myogenesis. [PDF]

FASEB J
Abstract Emerin, a ubiquitously expressed inner nuclear membrane protein, plays a central role in maintaining nuclear structure and genomic organization, and in regulating gene expression and cellular signaling pathways. These functions are critical for proper myogenic differentiation and are closely linked to the
Marano N, Holaska JM.
europepmc   +3 more sources