Results 61 to 70 of about 307,971 (276)
Nature Communications, 2020 The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi +9 more
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Targeting the inner nuclear membrane
The Journal of Cell Biology, 2004 ![][1] A reporter (green) gets trapped (bottom) in the nucleus by binding its partner (red). Proteins destined for the inner nuclear membrane (INM) start out in the peripheral ER.
openaire +2 more sources
Multiple routes to the inner nuclear membrane [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Gold particles mark the location of the INM protein NET39 in the ONM (downward arrowhead) and in the INM (upward arrowhead). At least four mechanisms can usher inner nuclear membrane (INM) proteins to their proper location, [Zuleger et al.][2] show.
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Secret passage to the inner nuclear membrane [PDF]
Journal of Cell Biology, 2010 Proteins enter the inner nuclear membrane through a side door in the nuclear pore complex, [Theerthagiri et al.][1] report. ![Figure][2] A swollen nucleus lacking Nup188 and Nup93 (left) dwarfs a normal nucleus (right).
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Evidence for the existence of Dm0-like Lamin in Sf9 cells
浙江大学学报. 农业与生命科学版, 2015 The nuclear membrane of mammalian cells was composed of inner nuclear membrane, outer nuclear membrane and perinuclear space. The lamina was localized under the nucleoplasm face of inner nuclear membrane. It has been known that the lamina was distributed
Wei Wenqiang, Ji Shaoping, Zhang Yinyan
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The anaphase-promoting complex regulates the degradation of the inner nuclear membrane protein Mps3
bioRxiv, 2018 The nucleus is enclosed by the inner nuclear membrane (INM) and the outer nuclear membrane (ONM). While the ONM is continuous with the endoplasmic reticulum (ER), the INM is independent and separates the nucleoplasm from the ER lumen.
Bailey A. Koch +3 more
semanticscholar +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nature Communications, 2016 Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging.
Krishna C Mudumbi +2 more
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