Results 71 to 80 of about 1,143 (172)
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity
The Journal of Physiology, Volume 603, Issue 15, Page 4237-4253, 1 August 2025.Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez +3 more
wiley +1 more source
Recent advances in structural characterization of volume‐regulated anion channels (VRACs)
The Journal of Physiology, Volume 603, Issue 15, Page 4201-4211, 1 August 2025.Abstract figure legend Native LRRC8 channels are obligatory heteromers comprising LRRC8A and at least one other paralogue (LRRC8B‐E) with an unknown stoichiometry. LRRC8A and LRRC8D homomers form non‐functional hexameric channels or hexameric channels with abnormal functional properties.
Erkan Karakas +2 more
wiley +1 more source
Distinct roles for innexin gap junctions and hemichannels in mechanosensation
eLife, 2019 Abstract Mechanosensation is central to a wide range of functions, including tactile and pain perception, hearing, proprioception, and control of blood pressure, but identifying the molecules underlying mechanotransduction has proved challenging.
Walker, Denise S, Schafer, William R
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A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel
Molecular Brain, 2011 Gap junctions mediate the electrical coupling and intercellular communication between neighboring cells. Some gap junction proteins, namely connexins and pannexins in vertebrates, and innexins in invertebrates, may also function as hemichannels.
Bouhours Magali +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 The success of cattle tick fixation largely depends on the secretion of substances that alter the immune response of the host. The majority of these substances are expressed by the parasite salivary gland and secreted in tick saliva.
Poliana Fernanda Giachetto +5 more
doaj +1 more source
MedComm, Volume 6, Issue 5, May 2025.Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes +4 more
wiley +1 more source
Neural Development, 2009 Background Approximately 10% of Caenorhabditis elegans nervous system synapses are electrical, that is, gap junctions composed of innexins. The locomotory nervous system consists of several pairs of interneurons and three major classes of motor neurons ...
Nicholson Bruce J +4 more
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A Single‐Cell Atlas of Crab Ovary Provides New Insights Into Oogenesis in Crustaceans
Advanced Science, Volume 12, Issue 2, January 13, 2025.Crabs are a valuable resource for aquatic ecosystems worldwide. This study presents a high‐resolution single‐cell atlas to study the oogenesis process in crabs. The results indicate the conserved trajectory of oogenesis from oogonia to oocytes. Moreover, based on the distribution features and subsequent functional analysis, the study determined several
Li Lu, Tao Wang, An Liu, Haihui Ye
wiley +1 more source
Gap junctional proteins of animals: The innexin/pannexin superfamily
Progress in Biophysics and Molecular Biology, 2007 There has been some controversy as to whether vertebrate pannexins are related to invertebrate innexins. Using statistical, topological and conserved sequence motif analyses, we establish that these proteins belong to a single superfamily. We also demonstrate the occurrence of large homologues with C-terminal proline-rich domains that may have arisen ...
Ming Ren, Yen, Milton H, Saier
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Evolutionary origin of the nervous system from Ctenophora prospective
Evolution &Development, Volume 26, Issue 4, July 2024.This review discusses the evolutionary origin of the nervous system in light of the latest findings in the neuroscience of Ctenophora, one of the most enigmatic and earliest diverging animal lineages. Abstract Nervous system is one of the key adaptations underlying the evolutionary success of the majority of animal groups. Ctenophores (or comb jellies)
Maria Y. Sachkova
wiley +1 more source