Results 61 to 70 of about 1,143 (172)

Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids [PDF]

Science Advances, 2020
Cryo-EM structures of the undocked INX-6 hemichannels reveal a pore obstruction and N-terminal rearrangement in lipids.
Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, Atsunori Oshima   +6 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

De Novo Transcriptome Assembly Reveals Insights Into Osmoregulation and Oxidative Stress Response in the Gills of the Southern King Crab (Lithodes santolla)

Ecology and Evolution, Volume 15, Issue 11, November 2025.
The Southern King Crab (Lithodes santolla), an ecologically and commercially important species in sub‐Antarctic waters. In this study, we assembled the first gill de novo transcriptome of L. santolla to characterize gene expression related to environmental responses.
Alexandra Brante, Paulina Bustos, Claudio Ortega‐Muñoz, Eliana Paola Acuña Gómez, Vicenzo Brante, Rodolfo Farlora   +5 more
wiley   +1 more source

Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages

BMC Genomics, 2021
Background The pond snail, Lymnaea stagnalis (L. stagnalis), has served as a valuable model organism for neurobiology studies due to its simple and easily accessible central nervous system (CNS). L.
Martina Rosato, Brittany Hoelscher, Zhenguo Lin, Chidera Agwu, Fenglian Xu   +4 more
doaj   +1 more source

Dysregulation of Glial Gap Junction Protein Innexin2 Mediates Seizures and Disrupted Sleep in a Drosophila Model for North Sea Progressive Myoclonus Epilepsy

Journal of Neuroscience Research, Volume 103, Issue 11, November 2025.
Glial Innexin2 expression plays a role in suppression of heat‐induced seizures and maintaining sleep architecture in Drosophila. A North Sea Progressive Myoclonus Epilepsy (NS‐PME) model shows a decreased level and altered expression pattern of glial Innexin2, along with heat‐induced seizures and disturbed sleep architecture.
Nicola A. Grzeschik, Roald A. Lambrechts, Marianne van der Zwaag, Ellie Eggens‐Meijer, Ody C. M. Sibon, Jenke A. Gorter   +5 more
wiley   +1 more source

Detecting the cold: Do innexins function in cold nociception? [PDF]

, 2019
Nociception is the perception of and response to harmful stimuli. Nociception is essential for minimizing tissue damage, but aberrant nociceptive pathways can result in chronic pain. Chronic pain in the U.S.
Barborek, Rachel
core  

Neuromoduláció sejtszintű mechanizmusainak vizsgálata ideg-izom és ideg-mirigy kapcsolatokban. = Cellular mechanisms of the neuromodulation in neuromuscular and neuroglandular junctions. [PDF]

, 2007
Az éticsiga nyálmirigy jó modell az ideg-izom, ideg-mirigy szinapszis és a szekréció molekuláris mechanizmusának a tanulmányozásában. A mirigyben négyféle sejttípust azonosítottunk és megállapítottuk, hogy azok száma, eloszlása az aktív és inaktív ...
Filla, Adrienn, Hiripi, László, Kiss, Tibor, Hegedus, Endre Roland, Elekes, Károly, Pirger, Zsolt   +5 more
core   +1 more source

The Pannexins: Past and Present

Frontiers in Physiology, 2014
The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond, Steven eBond, Christian C. Naus   +2 more
doaj   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Immunolocalization ofTaenia soliumgap junction innexins

Parasitology, 2008
SUMMARYIn previous studies, ultrastructural observations revealed a large number of gap junctions (GJs) in the neck and immature proglottid tissues ofTaenia soliumtapeworms. In these helminths, cytoplasmic glycogen sacs are connected by numerous discrete GJs to other cells throughout the maturing strobilar tissue.
R, Zurabian, A, Landa, L, Robert, K, Willms   +3 more
openaire   +2 more sources