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Inosine in Biology and Disease [PDF]

Genes, 2021
The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs (mRNAs).
Sundaramoorthy Srinivasan, Adrian Gabriel Torres, Lluís Ribas de Pouplana   +2 more
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Inosine: A bioactive metabolite with multimodal actions in human diseases

Frontiers in Pharmacology, 2022
The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and signaling pathways.
In Soo Kim, In Soo Kim, In Soo Kim, Eun-Kyoung Jo, Eun-Kyoung Jo, Eun-Kyoung Jo   +5 more
doaj   +2 more sources

Inosine in Neurodegenerative Diseases: From the Bench to the Bedside

Molecules, 2022
Neurodegenerative diseases, such as Alzheimer′s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs. Therefore, novel therapeutic strategies are needed in
Maria Sofia Basile, Placido Bramanti, Emanuela Mazzon   +2 more
doaj   +2 more sources

Impact of Inosine on Chronic Unpredictable Mild Stress-Induced Depressive and Anxiety-Like Behaviors With the Alteration of Gut Microbiota

Frontiers in Cellular and Infection Microbiology, 2021
Current antidepressants do not confer a clear advantage in children and adolescents with major depressive disorder (MDD). Accumulating evidence highlights the potential antidepressant-like effects of inosine on adult MDD, and gut microbiomes are ...
Xueer Liu, Xueer Liu, Xueer Liu, Teng Teng, Teng Teng, Teng Teng, Xuemei Li, Xuemei Li, Xuemei Li, Li Fan, Li Fan, Li Fan, Yajie Xiang, Yajie Xiang, Yajie Xiang, Yuanliang Jiang, Yuanliang Jiang, Kang Du, Kang Du, Yuqing Zhang, Xinyu Zhou, Xinyu Zhou, Peng Xie, Peng Xie, Peng Xie   +24 more
doaj   +2 more sources

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages [PDF]

Molecules
Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma, Xiaoli Qian, Qun Yu, Yadan Dong, Jiapeng Wang, Heng Liu, Huai Xiao   +6 more
doaj   +2 more sources

Association of Inosine and Cytidine

Biophysical Journal, 1971
A rigorous theory for the analysis of an associating system involving two different monomer units, which may also undergo self-association, has been developed. In the present paper the application of the theory to actual data is demonstrated for the first time.
M.E. Magar, R.F. Steiner, R. Kolinski
openaire   +4 more sources

The effect of intraoperative inosine infusion on transplant outcomes in deceased-donor kidney transplant recipients [PDF]

Renal Failure
Objectives It is unknown when inosine was first employed as a renoprotective agent in the context of kidney transplantation procedures. However, there is no clinical evidence to support a protective role of inosine.
You Luo, Yang Zhang, Zuofu Tang, Jinhua Zhang, Ning Na, Hengjun Xiao   +5 more
doaj   +2 more sources

STUDIES ON INOSINE FERMENTATION-PRODUCTION OF INOSINE BY MUTANTS OF BACILLUS SUBTILIS

The Journal of General and Applied Microbiology, 1963
Using three typical inosine-producing mutants of Bacillus subtilis, the effect of medium composition on the inosine productivity was investigated.1. To allow the bacteria grow and accumulate inosine, the synthetic medium should contain, besides suitable carbon and nitrogen sources, certain amounts of adenine and some amino acids.
Ryohei Aoki, Haruo Momose, YASUSHIRO KONDO, Nobutoshi MURAMATSU, Yoshio Tsuchiya   +4 more
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Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis

The FASEB Journal, 2021
Inosine monophosphate (IMP) is the intracellular precursor for both adenosine monophosphate and guanosine monophosphate and thus plays a central role in intracellular purine metabolism. IMP can also serve as an extracellular signaling molecule, and can regulate diverse processes such as taste sensation, neutrophil function, and ischemia-reperfusion ...
Pal Pacher, György Haskó, Marianna Lovászi, Jennet Beesley, William C. Gause, Zoltan H. Nemeth, Zoltan H. Nemeth   +6 more
openaire   +4 more sources

Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection [PDF]

Frontiers in Cellular Neuroscience
BackgroundFollowing transection, nerve repair using the polylactic acid (PLA) conduit is an effective option. In addition, inosine treatment has shown potential to promote nerve regeneration.
Fellipe Soares dos Santos Cardoso, Guilherme dos Santos Maria, Fernanda Marques Pestana, Ricardo Cardoso, Bruna dos Santos Ramalho, Bruna dos Santos Ramalho, Luiza dos Santos Heringer, Tiago Bastos Taboada, Ana Maria Blanco Martinez, Fernanda Martins de Almeida, Fernanda Martins de Almeida   +10 more
doaj   +2 more sources