Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages [PDF]
MoleculesInosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma +6 more
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The effect of intraoperative inosine infusion on transplant outcomes in deceased-donor kidney transplant recipients [PDF]
Renal FailureObjectives It is unknown when inosine was first employed as a renoprotective agent in the context of kidney transplantation procedures. However, there is no clinical evidence to support a protective role of inosine.
You Luo +5 more
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NMR Quantum Logic Gates for Homonuclear Spin Systems [PDF]
, 1999 If NMR systems are to be used as practical quantum computers, the number of coupled spins will need to be so large that it is not feasible to rely on purely heteronuclear spin systems. The implementation of a quantum logic gate imposes certain constraints on the motion of those spins not directly involved in that gate, the so-called "spectator" spins ...
Chuang +20 more
arxiv +4 more sources
Association of Inosine and Cytidine
Biophysical Journal, 1971 A rigorous theory for the analysis of an associating system involving two different monomer units, which may also undergo self-association, has been developed. In the present paper the application of the theory to actual data is demonstrated for the first time.
M.E. Magar +2 more
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study [PDF]
Cancer MedicineBackground This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao +6 more
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Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection [PDF]
Frontiers in Cellular NeuroscienceBackgroundFollowing transection, nerve repair using the polylactic acid (PLA) conduit is an effective option. In addition, inosine treatment has shown potential to promote nerve regeneration.
Fellipe Soares dos Santos Cardoso +10 more
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STUDIES ON INOSINE FERMENTATION-PRODUCTION OF INOSINE BY MUTANTS OF BACILLUS SUBTILIS
The Journal of General and Applied Microbiology, 1963 Using three typical inosine-producing mutants of Bacillus subtilis, the effect of medium composition on the inosine productivity was investigated.1. To allow the bacteria grow and accumulate inosine, the synthetic medium should contain, besides suitable carbon and nitrogen sources, certain amounts of adenine and some amino acids.
Ryohei Aoki +4 more
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STUDIES ON INOSINE FERMENTATION-PRODUCTION OF INOSINE BY MUTANTS OF BACILLUS SUBTILIS
The Journal of General and Applied Microbiology, 1967 The adenine-sparing action of amino acid mixture (Difco "casamino acid" type) for inosine formation by adenine- and adenine-histidine-requiring mutants of Bacillus subtilis was revealed to be brought about by a combination of the following L-amino acids contained in the original mixture: histidine plus mixture of eight amino acids, isoleucine, leucine,
Akio Yamanoi +2 more
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Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ [PDF]
mSystemsAntimicrobial resistance is rapidly increasing worldwide, highlighting the urgent need for pharmaceutical and nonpharmaceutical interventions to tackle different-to-treat bacterial infections.
Fulei Li +4 more
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DE NOVO SYNTHESIS OF HYPOXANTHINE VIA INOSINE-5-PHOSPHATE AND INOSINE [PDF]
Journal of Biological Chemistry, 1951 Gordon R. Greenberg
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