Results 1 to 10 of about 43,083 (163)

Inosine in Biology and Disease [PDF]

Genes, 2021
The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs (mRNAs).
Adrian G Torres, Lluis Ribas de Pouplana
exaly   +3 more sources

Mechanism of Inosine from Lactiplantibacillus plantarum MWFLp-182-Treated Mice Model in Alleviating D-Galactose-Induced HT-22 Cell Injury via Oxidative and Inflammatory Pathways [PDF]

Foods
Gut microbial metabolites play a crucial role in modulating cognitive function. In a previous animal study, oral administration of Lactiplantibacillus plantarum MWFLp-182 (L.
Jianbo Tang, Qing Zhao, Hanying Tan, Ni Yang, Qun Yu, Zhiyu Cui, Xiaochun Li, Yanghe Luo, Guangqing Mu, Xiaomeng Wu, Hui Nie   +10 more
doaj   +2 more sources

Inosine alleviates colorectal cancer liver metastasis by promoting M1 macrophage polarization and modulating the PI3K/AKT signaling pathway [PDF]

Frontiers in Immunology
IntroductionColorectal cancer (CRC) represents one of the most common malignancies of the digestive tract, with colorectal cancer liver metastasis (CRLM) constituting a major cause of CRC-related mortality, for which therapeutic options remain limited ...
Yadan Dong, Yuchen Ma, Qun Yu, Zhengmei Shi, Caiyi Wang, Yihao Che, Heng Liu, Desheng Wan, Weizai Shao, Weizai Shao, Huai Xiao   +10 more
doaj   +2 more sources

Inosine: biofunctions and the roles in human diseases [PDF]

Frontiers in Endocrinology
Inosine, a basic component of purine nucleotide, is mainly seen only as a building block in nucleotide synthesis. It is also a versatile bioactive molecule with diverse biofunctions.
Fangwei Li, Jiawen Zhang, Jiayi Kang, Xuemei Tong, Ping Zhang, Yemin Zhu   +5 more
doaj   +2 more sources

Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis

Frontiers in Immunology, 2022
Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region.
Fan Yang, Leyu Zhou, Yi Shen, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xiaoli Fan, Li Yang   +7 more
doaj   +1 more source

Inosine: A bioactive metabolite with multimodal actions in human diseases

Frontiers in Pharmacology, 2022
The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and signaling pathways.
In Soo Kim, In Soo Kim, In Soo Kim, Eun-Kyoung Jo, Eun-Kyoung Jo, Eun-Kyoung Jo   +5 more
doaj   +1 more source

Inosine in Neurodegenerative Diseases: From the Bench to the Bedside

Molecules, 2022
Neurodegenerative diseases, such as Alzheimer′s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs. Therefore, novel therapeutic strategies are needed in
Maria Sofia Basile, Placido Bramanti, Emanuela Mazzon   +2 more
doaj   +1 more source

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

Open Biology, 2021
Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo, Jung In Kim, Narumi Aoki Shioi, Shigenori Iwai, Isao Kuraoka   +4 more
doaj   +1 more source

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

Cells, 2020
Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside’s putative relevance in wound healing, dermal fibrosis, and myofascial pain, we ...
Carina Herman-de-Sousa, Ana Rita Pinheiro, Diogo Paramos-de-Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Teresa Magalhães-Cardoso, Severino Ribeiro, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá   +9 more
doaj   +1 more source

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source