Results 1 to 10 of about 86,294 (302)
Inosine: A bioactive metabolite with multimodal actions in human diseases
Frontiers in Pharmacology, 2022 The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and signaling pathways.
In Soo Kim +5 more
doaj +2 more sources
Inosine in Neurodegenerative Diseases: From the Bench to the Bedside
Molecules, 2022 Neurodegenerative diseases, such as Alzheimer′s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs. Therefore, novel therapeutic strategies are needed in
Maria Sofia Basile +2 more
doaj +2 more sources
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction
Nature Metabolism, 2020 T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and ...
Tingting Wang, Xuyong Chen, Siwen Kang
exaly +2 more sources
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Nature, 2022 Brown adipose tissue (BAT) dissipates energy1,2 and promotes cardiometabolic health3. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis.
, , Christa E Müller
exaly +2 more sources
Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
Nature Communications, 2022 Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known.
Qisheng Gu, Di Yu, Yue Gao
exaly +2 more sources
iMetaEmerging evidence has demonstrated the profound impact of the gut microbiome on cardiovascular diseases through the production of diverse metabolites. Using an animal model of myocardial ischemia–reperfusion (I/R) injury, we found that the prophylactic ...
Hao Zhang +12 more
doaj +2 more sources
Inosine: biofunctions and the roles in human diseases [PDF]
Frontiers in EndocrinologyInosine, a basic component of purine nucleotide, is mainly seen only as a building block in nucleotide synthesis. It is also a versatile bioactive molecule with diverse biofunctions.
Fangwei Li +5 more
doaj +2 more sources
Біологічні студії, 2012 In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially ...
V. V. Trush
doaj +3 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Current antidepressants do not confer a clear advantage in children and adolescents with major depressive disorder (MDD). Accumulating evidence highlights the potential antidepressant-like effects of inosine on adult MDD, and gut microbiomes are ...
Xueer Liu +24 more
doaj +2 more sources
Open Biology, 2021 Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo +4 more
doaj +2 more sources