Results 91 to 100 of about 31,925 (249)

Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression

Cancer Science, EarlyView.
Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang, Hanyu Zhang, Mingcui Li, Yanling Li, Zhuo‐Ran Wang, Weilun Cheng, Yansong Liu, Zhengbo Fang, Ang Zheng, Jingxuan Wang, Fei Ma   +10 more
wiley   +1 more source

Influence of nonsteroid anabolic inosine on manifestation of the effects of dexamethasone on skeletal muscle of white rats

Біологічні студії, 2012
In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially ...
V. V. Trush
doaj   +1 more source

ERYTHROCYTE PRESERVATION. VII. ACID-CITRATE-DEXTROSE-INOSINE (ACDI) AS A PRESERVATIVE FOR BLOOD DURING STORAGE AT 4° C1 [PDF]

, 1956
Beverly W. Gabrio, Dennis M. Donohue, F.M. Huennekens, Clement A. Finch   +3 more
openalex   +1 more source

Cutting‐Edge Advancements in the Antibiotics‐Gut Microbiota‐Urinary Tumour Axis

Cell Proliferation, EarlyView.
Gut microbiota regulates urological tumors. Antibiotics induce dysbiosis, altering tumor progression/therapy: reducing carcinogen metabolism but impairing immunity. Specific bacteria enhance immune responses and combat endocrine resistance. Future research should unravel microbiota‐cancer links and develop microbiome‐targeted therapies to optimize ...
Jie Wang, Dengxiong Li, Ruicheng Wu, Dechao Feng   +3 more
wiley   +1 more source

Codon decoding by orthogonal tRNAs interrogates the in vivo preferences of unmodified adenosine in the wobble position

Frontiers in Genetics
The in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the wobble position, are largely unexplored because very few unmodified A34 tRNA genes exist across the three domains of life.
Margaret A. Schmitt, Jillyn M. Tittle, John D. Fisk   +2 more
doaj   +1 more source

Enzymic Synthesis of Xanthosine- and Guanosine-5-phosphate from Inosine-5-phosphate. [PDF]

, 1955
Ulf Lagerkvist, Georg Lundgren, Ragnar Lundén, Harald Prydz   +3 more
openalex   +1 more source

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Inhibition of inosine metabolism of the gut microbiota decreases testosterone secretion in the testis

mSystems
Growing evidence indicates that gut microbiota is involved in the regulation of the host’s sex hormone levels, such as through interfering with the sex hormone metabolism in the intestine.
Lei Tang, Xizhong Yang, Mengting Zhou, Lingxin Feng, Cuijie Ji, Jie Liang, Bei Zhang, Ruowu Shen, Luoyang Wang   +8 more
doaj   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

The Relationship of the Age of Rabbit Erythrocytes to the Effects of Inosine on their Osmotic Resistance12 [PDF]

, 1958
Ernst R. Jaffé, Grace A. Vanderhoff, Bertram A. Lowy, Irving M. London   +3 more
openalex   +1 more source