Results 11 to 20 of about 66,823 (327)
Inosine in Biology and Disease [PDF]
Genes, 2021 The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs (mRNAs).
Sundaramoorthy Srinivasan +2 more
openaire +3 more sources
Inosine: A bioactive metabolite with multimodal actions in human diseases
Frontiers in Pharmacology, 2022 The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and signaling pathways.
In Soo Kim +5 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Current antidepressants do not confer a clear advantage in children and adolescents with major depressive disorder (MDD). Accumulating evidence highlights the potential antidepressant-like effects of inosine on adult MDD, and gut microbiomes are ...
Xueer Liu +24 more
doaj +2 more sources
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury [PDF]
iMetaEmerging evidence has demonstrated the profound impact of the gut microbiome on cardiovascular diseases through the production of diverse metabolites. Using an animal model of myocardial ischemia–reperfusion (I/R) injury, we found that the prophylactic ...
Hao Zhang +12 more
doaj +2 more sources
Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer [PDF]
MicroorganismsProstate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses to castration-resistant prostate cancer (CRPC) with a poor prognosis.
Yao Yu +8 more
doaj +2 more sources
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Nature, 2022 Brown adipose tissue (BAT) dissipates energy1,2 and promotes cardiometabolic health3. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis.
Birte Niemann +19 more
semanticscholar +1 more source
Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
Nature Communications, 2022 Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known.
Lei Zhang +21 more
semanticscholar +1 more source
Succinate and inosine coordinate innate immune response to bacterial infection
PLoS Pathogens, 2022 Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by stimulating release of cytokines and complement components.
Ming Jiang +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region.
Fan Yang +7 more
doaj +1 more source
Landscape of adenosine-to-inosine RNA recoding across human tissues
Nature Communications, 2022 RNA editing by adenosine deaminases changes the information encoded in the mRNA from its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally distinct, protein isoforms and diversify the proteome.
Orshay Gabay +11 more
semanticscholar +1 more source