Results 11 to 20 of about 86,294 (302)

Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents

Molecular Psychiatry, 2018
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma
David Cohen, Arun V Ravindran, Peng Zheng   +2 more
exaly   +2 more sources

Inosine induces stemness features in CAR-T cells and enhances potency

Cancer Cell
D. Klysz, C. Fowler, Meena B. Malipatlolla, Lucille Stuani, Katherine A Freitas, Yiyun Chen, Stefanie L. Meier, Bence Daniel, Katalin D. Sandor, Peng Xu, Jing Huang, Louai Labanieh, V. Keerthi, A. Leruste, Malek Bashti, Janette Mata-Alcazar, N. Gkitsas, Justin A Guerrero, Chris Fisher, Sunny Patel, K. Asano, Shabnum Patel, Kara L. Davis, Ansuman T. Satpathy, Steven A. Feldman, E. Sotillo, Crystal L. Mackall   +26 more
exaly   +2 more sources

Supplementing Inosine to Blood Collection Tubes Adds a Glycolytic Inhibitory Effect. [PDF]

J Diabetes
Kume Y, Ohkubo M, NaKatuka N, Aritake-Okada S, Yoshida T, Isago H, Kurano M.   +6 more
europepmc   +3 more sources

Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis

Frontiers in Immunology, 2022
Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region.
Fan Yang, Leyu Zhou, Yi Shen, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xiaoli Fan, Li Yang   +7 more
doaj   +1 more source

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

bioRxiv, 2023
Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8+ CAR T cells mediate Ado-induced immunosuppression through CD39/73-dependent Ado production.
D. Klysz, C. Fowler, Meena B. Malipatlolla, Lucille Stuani, Katherine A Freitas, S. Meier, Bence Daniel, Katalin D. Sandor, Peng Xu, Jing Huang, Louai Labanieh, A. Leruste, Malek Bashti, V. Keerthi, Janette Mata-Alcazar, N. Gkitsas, Justin A Guerrero, Chris J Fisher, Sunny Patel, K. Asano, Shabnum Patel, K. Davis, Ansuman T. Satpathy, Steven A. Feldman, E. Sotillo, C. Mackall   +25 more
semanticscholar   +1 more source

Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms

International Journal of Molecular Sciences, 2023
Background: Colonic and serum inosine are significantly reduced in patients with inflammatory bowel disease (IBD). Methods: This study aimed to explore whether microbiome-derived inosine alleviates colitis and its underlying mechanisms.
Weiling Guo, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Bingyong Mao, Hao Zhang, Shumao Cui   +6 more
semanticscholar   +1 more source

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation

Cell Death and Disease, 2023
Metabolic heterogeneity of tumor microenvironment (TME) is a hallmark of cancer and a big barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative carbon sources, including nucleotides, under poor nutrient circumstances.
Meixin Li, Xiaoting Wu, Wenchuan Jing, Wenkui Hou, Sheng Hu, Wei Yan   +5 more
semanticscholar   +1 more source

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Microbiome, 2021
Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation.
Daotong Li, Yu Feng, Meiling Tian, Junfu Ji, Xiaosong Hu, Fang Chen   +5 more
semanticscholar   +1 more source

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and ...
B. Bluett, D. Togasaki, Dragoș Mihăilă, M. Evatt, M. Rezak, Samay Jain, M. Schwarzschild, A. Ascherio, C. Casaceli, G. Curhan, R. Fitzgerald, Cornelia L. Kamp, C. Lungu, E. Macklin, K. Marek, D. Mozaffarian, D. Oakes, A. Rudolph, I. Shoulson, A. Videnovic, B. Scott, L. Gauger, J. Aldred, Melissa Bixby, Jill Ciccarello, S. Gunzler, C. Henchcliffe, M. Brodsky, Kellie Keith, R. Hauser, C. Goetz, M. LeDoux, V. Hinson, R. Kumar, A. Espay, J. Jimenez-shahed, C. Hunter, C. Christine, Aaron T Daley, M. Leehey, J. A. de Marcaida, J. Friedman, A. Hung, Grace Bwala, I. Litvan, D. Simon, T. Simuni, C. Poon, M. Schiess, K. Chou, A. Park, D. Bhatti, C. Peterson, S. Criswell, L. Rosenthal, Jennifer Durphy, H. Shill, S. Mehta, Anwar Ahmed, A. Deik, John Y. Fang, N. Stover, Lin Zhang, R. Dewey, Ashley Gerald, J. Boyd, Emily Houston, V. Suski, S. Mosovsky, L. Cloud, Binit B. Shah, Marie Saint-Hilaire, Raymond James, S. Zauber, S. Reich, D. Shprecher, R. Pahwa, A. Langhammer, K. LaFaver, P. LeWitt, Patricia Kaminski, J. Goudreau, Doozie Russell, D. Houghton, A. Laroche, Karen M Thomas, Martha McGraw, Z. Mari, C. Serrano, K. Blindauer, Marcie L. Rabin, R. Kurlan, J. Morgan, M. Soileau, Melissa Ainslie, I. Bodis-Wollner, Ruth B. Schneider, C. Waters, Amber Servi Ratel, C. Beck, P. Bolger, K. F. Callahan, Grace F Crotty, D. Klements, Melissa Kostrzebski, G. McMahon, Lindsay Pothier, S. Waikar, A. Lang, T. Mestre   +109 more
semanticscholar   +1 more source

Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma

Metabolites, 2021
In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling, Nadine Knutti, Franziska Scherr, Jörg Geiger, Juliane Weikert, Michael Rose, Roland Jahns, Uta Ceglarek, André Scherag, Michael Kiehntopf   +9 more
doaj   +1 more source