STUDIES ON INOSINE FERMENTATION-PRODUCTION OF INOSINE BY MUTANTS OF BACILLUS SUBTILIS
The Journal of General and Applied Microbiology, 1967 The adenine-sparing action of amino acid mixture (Difco "casamino acid" type) for inosine formation by adenine- and adenine-histidine-requiring mutants of Bacillus subtilis was revealed to be brought about by a combination of the following L-amino acids contained in the original mixture: histidine plus mixture of eight amino acids, isoleucine, leucine,
Akio Yamanoi +2 more
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Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration [PDF]
Advanced ScienceThe role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive. Here, it is shown that fecal microbiota transplantation (FMT) from healthy mice to lupus mice ameliorates lupus‐like symptoms.
Lingyu Gao +15 more
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study [PDF]
Cancer MedicineBackground This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao +6 more
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Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases [PDF]
AntioxidantsNon-communicable neurological disorders are the second leading cause of death, and their burden continues to increase as the world population grows and ages.
Massimo Bortolotti +3 more
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DE NOVO SYNTHESIS OF HYPOXANTHINE VIA INOSINE-5-PHOSPHATE AND INOSINE [PDF]
Journal of Biological Chemistry, 1951 Gordon R. Greenberg
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Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ [PDF]
mSystemsAntimicrobial resistance is rapidly increasing worldwide, highlighting the urgent need for pharmaceutical and nonpharmaceutical interventions to tackle different-to-treat bacterial infections.
Fulei Li +4 more
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Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Nature, 2022 Brown adipose tissue (BAT) dissipates energy1,2 and promotes cardiometabolic health3. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis.
Birte Niemann +19 more
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Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
Nature Communications, 2022 Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known.
Lei Zhang +21 more
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Frontiers in Immunology, 2022 Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region.
Fan Yang +7 more
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Journal of the American Medical Association (JAMA), 2021 Importance Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and ...
B. Bluett +109 more
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