Results 21 to 30 of about 66,823 (327)

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and ...
B. Bluett, D. Togasaki, Dragoș Mihăilă, M. Evatt, M. Rezak, Samay Jain, M. Schwarzschild, A. Ascherio, C. Casaceli, G. Curhan, R. Fitzgerald, Cornelia L. Kamp, C. Lungu, E. Macklin, K. Marek, D. Mozaffarian, D. Oakes, A. Rudolph, I. Shoulson, A. Videnovic, B. Scott, L. Gauger, J. Aldred, Melissa Bixby, Jill Ciccarello, S. Gunzler, C. Henchcliffe, M. Brodsky, Kellie Keith, R. Hauser, C. Goetz, M. LeDoux, V. Hinson, R. Kumar, A. Espay, J. Jimenez-shahed, C. Hunter, C. Christine, Aaron T Daley, M. Leehey, J. A. de Marcaida, J. Friedman, A. Hung, Grace Bwala, I. Litvan, D. Simon, T. Simuni, C. Poon, M. Schiess, K. Chou, A. Park, D. Bhatti, C. Peterson, S. Criswell, L. Rosenthal, Jennifer Durphy, H. Shill, S. Mehta, Anwar Ahmed, A. Deik, John Y. Fang, N. Stover, Lin Zhang, R. Dewey, Ashley Gerald, J. Boyd, Emily Houston, V. Suski, S. Mosovsky, L. Cloud, Binit B. Shah, Marie Saint-Hilaire, Raymond James, S. Zauber, S. Reich, D. Shprecher, R. Pahwa, A. Langhammer, K. LaFaver, P. LeWitt, Patricia Kaminski, J. Goudreau, Doozie Russell, D. Houghton, A. Laroche, Karen M Thomas, Martha McGraw, Z. Mari, C. Serrano, K. Blindauer, Marcie L. Rabin, R. Kurlan, J. Morgan, M. Soileau, Melissa Ainslie, I. Bodis-Wollner, Ruth B. Schneider, C. Waters, Amber Servi Ratel, C. Beck, P. Bolger, K. F. Callahan, Grace F Crotty, D. Klements, Melissa Kostrzebski, G. McMahon, Lindsay Pothier, S. Waikar, A. Lang, T. Mestre   +109 more
semanticscholar   +1 more source

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Microbiome, 2021
Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation.
Daotong Li, Yu Feng, Meiling Tian, Junfu Ji, Xiaosong Hu, Fang Chen   +5 more
semanticscholar   +1 more source

Bacillus cereus spores release alanine that synergizes with inosine to promote germination. [PDF]

PLoS ONE, 2009
BACKGROUND:The first step of the bacterial lifecycle is the germination of bacterial spores into their vegetative form, which requires the presence of specific nutrients.
Tetyana Dodatko, Monique Akoachere, Stefan M Muehlbauer, Forrest Helfrich, Amber Howerton, Christian Ross, Vicki Wysocki, Jürgen Brojatsch, Ernesto Abel-Santos   +8 more
doaj   +1 more source

Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

Nature Metabolism, 2020
T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and ...
Tingting Wang, J. R. Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, H. Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, S. Vicente-Muñoz, M. Warmoes, Penghui Lin, Z. Piedra-Quintero, M. Guerau-de-Arellano, K. Cassady, S. Zheng, Jun J. Yang, A. Lane, Xiaotong Song, T. Fan, Ruoning Wang   +22 more
semanticscholar   +1 more source

Inosine in Neurodegenerative Diseases: From the Bench to the Bedside

Molecules, 2022
Neurodegenerative diseases, such as Alzheimer′s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs. Therefore, novel therapeutic strategies are needed in
Maria Sofia Basile, Placido Bramanti, Emanuela Mazzon   +2 more
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Disease-associated inosine misincorporation into RNA hinders translation

Nucleic Acids Research, 2022
Failure to prevent accumulation of the non-canonical nucleotide inosine triphosphate (ITP) by inosine triphosphate pyrophosphatase (ITPase) during nucleotide synthesis results in misincorporation of inosine into RNA and can cause severe and fatal ...
Jacob H Schroader, Lindsey A. Jones, Ryan Meng, H. Shorrock, Jared I. Richardson, Sharon Shaughnessy, Q. Lin, Thomas J. Begley, J. Berglund, Gabriele Fuchs, Mark T. Handley, Kaalak Reddy   +11 more
semanticscholar   +1 more source

A randomized pilot trial assessing the reduction of gout episodes in hyperuricemic patients by oral administration of Ligilactobacillus salivarius CECT 30632, a strain with the ability to degrade purines

Frontiers in Microbiology, 2023
IntroductionHyperuricemia and gout are receiving an increasing scientific and medical attention because of their relatively high prevalence and their association with relevant co-morbidities.
Juan M. Rodríguez, Marco Garranzo, José Segura, Belén Orgaz, Rebeca Arroyo, Claudio Alba, David Beltrán, Leónides Fernández   +7 more
doaj   +1 more source

Adenosine-to-inosine RNA editing in neurological development and disease

RNA Biology, 2021
Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called adenosine deaminases acting on RNA (ADARs).
Yuxi Yang, Shunpei Okada, M. Sakurai
semanticscholar   +1 more source

Reduction of Redox Potential Exerts a Key Role in Modulating Gut Microbial Taxa and Function by Dietary Supplementation of Pectin in a Pig Model

Microbiology Spectrum, 2023
Pectin exists in a vast range of plants and has a long history of acting as a functional food additive with potential prebiotic effects on intestinal health.
Rongying Xu, Qiuke Li, Hongyu Wang, Yong Su, Weiyun Zhu   +4 more
doaj   +1 more source