Results 21 to 30 of about 86,294 (302)
Succinate and inosine coordinate innate immune response to bacterial infection
PLoS Pathogens, 2022 Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by stimulating release of cytokines and complement components.
Ming Jiang +6 more
semanticscholar +1 more source
Landscape of adenosine-to-inosine RNA recoding across human tissues
Nature Communications, 2022 RNA editing by adenosine deaminases changes the information encoded in the mRNA from its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally distinct, protein isoforms and diversify the proteome.
Orshay Gabay +11 more
semanticscholar +1 more source
Foods, 2020 Currently, soybean meal constitutes the main protein source for poultry production. However, the environmental and social issues related to soybean production are calling for more sustainable protein sources that can offset soybean requirements in animal
Vasiliki Gkarane +3 more
doaj +1 more source
Inosine in Biology and Disease
Genes, 2021 The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs
Sundaramoorthy M. Srinivasan +2 more
semanticscholar +1 more source
Adenosine-to-inosine RNA editing in neurological development and disease
RNA Biology, 2021 Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called adenosine deaminases acting on RNA (ADARs).
Yuxi Yang, Shunpei Okada, M. Sakurai
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2022 Because, as of yet, there are few new antibiotics active against multidrug-resistant bacteria are being explored, compounds including metabolites that might help us tide over this crisis are greatly expected.
Jian-jun Tao +7 more
doaj +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Dale, Nicholas +2 more
core +3 more sources
The Bacillus cereus GerN and GerT protein homologs have distinct roles in spore germination and outgrowth, respectively [PDF]
, 2008 The GerT protein of Bacillus cereus shares 74% amino acid identity with its homolog GerN. The latter is a Na+/H+-K+ 19 antiporter that is required for normal spore germination in inosine.
Moir, A., Senior, A.
core +2 more sources
Cells, 2020 Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside’s putative relevance in wound healing, dermal fibrosis, and myofascial pain, we ...
Carina Herman-de-Sousa +9 more
doaj +1 more source
Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
core +2 more sources