Results 41 to 50 of about 71,261 (330)

New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]

open access: yes, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana   +4 more
core   +2 more sources

The effects of inosine on clinical and histological findings after experimental spinal cord injury in rats

open access: yesVeterinární Medicína, 2015
Inosine is a naturally occurring purine nucleoside, the effect of which was discovered only in recent decades. It has potential to prevent neuronal and glial death and can stimulate axonal outgrowth. This study evaluated the effect of inosine (400 mg per
V. Ledecky   +3 more
doaj   +1 more source

Germinant receptor diversity and germination responses of four strains of the Bacillus cereus group [PDF]

open access: yes, 2010
Four strains of the Bacillus cereus group were compared for their germinant receptor composition and spore germination capacity. Phylogenetic analysis of the germinant receptor encoding operons of the enterotoxic strains B.
Abee, T.   +3 more
core   +2 more sources

Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model

open access: yesPharmaceutical Biology, 2021
Context The uric acid metabolism pathway is more similar in primates and humans than in rodents. However, there are no reports of using primates to establish animal models of hyperuricaemia (HUA). Objectives To establish an animal model highly related to
Dong-hong Tang   +7 more
doaj   +1 more source

“Superwobbling” and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code

open access: yesLife, 2022
The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code.
Lei Lei, Zachary Frome Burton
doaj   +1 more source

The Bacillus cereus GerN and GerT protein homologs have distinct roles in spore germination and outgrowth, respectively [PDF]

open access: yes, 2008
The GerT protein of Bacillus cereus shares 74% amino acid identity with its homolog GerN. The latter is a Na+/H+-K+ 19 antiporter that is required for normal spore germination in inosine.
Moir, A., Senior, A.
core   +2 more sources

Inosine Substitutions in RNA Activate Latent G-Quadruplexes.

open access: yesJournal of the American Chemical Society, 2021
It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression.
T. Hagen   +9 more
semanticscholar   +1 more source

Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells

open access: yesMolecules, 2022
The antibiotic resistance rates of Klebsiella pneumoniae have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant Klebsiella pneumoniae and its associated benefits for bacterial pathogenicity are far from ...
Yuhan Zhang   +11 more
doaj   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

open access: yes, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A.   +9 more
core   +1 more source

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

open access: yeseLife, 2017
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit   +9 more
doaj   +1 more source

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