Results 41 to 50 of about 69,045 (225)

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]

, 2015
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S, Eisenberg, E, Galardi, S, Galeano, F, Gallo, A., Locatelli, F, Polito, V, Presutti, Carlo, Raho, S, Tomaselli, S, Vincenti, S   +10 more
core   +2 more sources

Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study

Cancer Medicine
Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li   +6 more
doaj   +1 more source

Structural effects of inosine substitution in telomeric DNA quadruplex

Frontiers in Chemistry
The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s).
Ya Ying Zheng, Ya Ying Zheng, Ricky Dartawan, Ricky Dartawan, Yuhan Wu, Yuhan Wu, Chengze Wu, Chengze Wu, Hope Zhang, Hope Zhang, Jeanne Lu, Jeanne Lu, Ashley Hu, Ashley Hu, Sweta Vangaveti, Jia Sheng, Jia Sheng   +16 more
doaj   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Germinant receptor diversity and germination responses of four strains of the Bacillus cereus group [PDF]

, 2010
Four strains of the Bacillus cereus group were compared for their germinant receptor composition and spore germination capacity. Phylogenetic analysis of the germinant receptor encoding operons of the enterotoxic strains B.
Abee, T., Garcia, D., Moezelaar, R., Voort, M., van der   +3 more
core   +2 more sources

Modulating Taste Perception in Newly Weaned Piglets: The Role of Palatability Additives in Enhancing Feed Intake and Performance

Animal Research and One Health, EarlyView.
Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht, Gabriela Altenhofen, Daiane Carvalho, Michele Fangmeier   +3 more
wiley   +1 more source

Influence of nonsteroid anabolic inosine on manifestation of the effects of dexamethasone on skeletal muscle of white rats

Біологічні студії, 2012
In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially ...
V. V. Trush
doaj   +1 more source

New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]

, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana, Gallo, Angela, Keegan, Liam P., Mannion, Niamh, O'Connell, Mary A.   +4 more
core   +2 more sources

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources