Results 51 to 60 of about 86,294 (302)

Multi-Substrate Specificity and the Evolutionary Basis for Interdependence in tRNA Editing and Methylation Enzymes

Frontiers in Genetics, 2019
Among tRNA modification enzymes there is a correlation between specificity for multiple tRNA substrates and heteromultimerization. In general, enzymes that modify a conserved residue in different tRNA sequences adopt a heterodimeric structure. Presumably,
Sameer Dixit, Jeremy C. Henderson, Juan D. Alfonzo   +2 more
doaj   +1 more source

Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]

, 2017
A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea, Rovira, Alexander R, Tor, Yitzhak   +2 more
core   +1 more source

Inosine Substitutions in RNA Activate Latent G-Quadruplexes.

Journal of the American Chemical Society, 2021
It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression.
T. Hagen, A. Laski, Anneke Brümmer, Adam Pruška, Verena Schlösser, A. Cléry, F. Allain, R. Zenobi, S. Bergmann, Jonathan Hall   +9 more
semanticscholar   +1 more source

Gastroprotective effects of oral nucleotide administration [PDF]

, 2006
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A, Fitzgerald, A, Ghosh, S, Marchbank, T, Playford, RJ   +4 more
core   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Effects of Succinate-Based Antioxidant on in vitro Conversion of Methemoglobin in Oxyhemoglobin

Общая реаниматология, 2018
The purpose of the study — to determine the feasibility of using the succinate-based antioxidant for the in vitro reduction of excessive methemoglobin to oxyhemoglobin in blood.Materials and Methods. Blood sampling was performed in five healthy donors in
A. M. Chernysh, E. K. Kozlova, V. V. Moroz, V. A. Sergunova, O. E. Gudkova, E. A. Manchenko, A. P. Kozlov   +6 more
doaj   +1 more source

A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson’s Disease Clinical Trial: A Pilot Study

Digital Biomarkers, 2022
Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.
Alex Page, Norman Yung, Peggy Auinger, Charles Venuto, Alistair Glidden, Eric Macklin, Larsson Omberg, Michael A. Schwarzschild, E. Ray Dorsey   +8 more
doaj   +1 more source

Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. [PDF]

, 2013
The width of the DNA minor groove varies with sequence and can be a major determinant of DNA shape recognition by proteins. For example, the minor groove within the center of the Fis-DNA complex narrows to about half the mean minor groove width of ...
Cascio, Duilio, Di Felice, Rosa, Ghane, Tahereh, Hancock, Stephen P, Johnson, Reid C, Rohs, Remo   +5 more
core   +2 more sources

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

Molecules
Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma, Xiaoli Qian, Qun Yu, Yadan Dong, Jiapeng Wang, Heng Liu, Huai Xiao   +6 more
doaj   +1 more source

Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma

Frontiers in Oncology, 2022
Pancreatic ductal adenocarcinoma presents a 5-year overall survival rate of 11%, placing an imperative need for the discovery and application of innovative treatments.
Erika Y. Faraoni, Lincoln N. Strickland, Baylee J. O’Brien, Joseph F. Barraza, Nirav C. Thosani, Curtis J. Wray, Tingting W. Mills, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg   +9 more
doaj   +1 more source