Results 51 to 60 of about 69,045 (225)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study [PDF]

, 2013
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep.
A Alonso, A Khateb, A Serrano, AV Kalinchuk, AV Kalinchuk, AV Kalinchuk, BB Fredholm, BG Frenguelli, BP Klyuch, BP Klyuch, C Romano, C Xu, CF Hohmann, D Curran-Everett, D Lovatt, D Stenberg, DG Van Wylen, E Llaudet, E Murillo-Rodriguez, EA Newman, F Longordo, H McIlwain, HK Wigren, Houdini Ho Tin Wu, I Haulica, ID Manns, J Grivel, JB Mitchell, JC Hoffmann, JP Mothet, JT McKenna, JT Porter, LA Etherington, LI Kiyashchenko, LI Schmitt, LO Alanko, M Ballarin, M Radulovacki, M van den Top, M Wall, MA Greco, MG Lee, MJ Wall, MM Halassa, MM Halassa, MM Thakkar, MO Enkvist, Nicholas Dale, O Pascual, P Franken, P Maquet, R Basheer, R Basheer, R Basheer, R Shigemoto, RH Farkas, RM Virus, Robert Edward Sims, S Palchykova, SR Glaum, SR Ticho, T Porkka-Heiskanen, T Porkka-Heiskanen, T Porkka-Heiskanen, TE Bjorness, TR Minor, TV Dunwiddie, V Parpura, V Ramesh, Valérie Mongrain, VM Sciotti, WE Cullinan, ZL Huang   +72 more
core   +5 more sources

Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases

Antioxidants
Non-communicable neurological disorders are the second leading cause of death, and their burden continues to increase as the world population grows and ages.
Massimo Bortolotti, Letizia Polito, Maria Giulia Battelli, Andrea Bolognesi   +3 more
doaj   +1 more source

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias, Heinzle, Elmar, Peifer, Susanne, Schneider, Konstantin, Volmer, Dietrich A., Zimmet, Sarah   +5 more
core   +1 more source

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, EarlyView.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

Making Molecules with Clay: Layered Double Hydroxides, Pentopyranose Nucleic Acids and the Origin of Life

Life, 2019
A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
doaj   +1 more source

Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]

, 2017
In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela, Corach, Daniel, Flichman, Diego Martin, Hulaniuk, María L., Trinks, Julieta   +4 more
core   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus

Viruses
The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral
Belinda Baquero-Pérez, Enrico Bortoletto, Umberto Rosani, Anna Delgado-Tejedor, Rebeca Medina, Eva Maria Novoa, Paola Venier, Juana Díez   +7 more
doaj   +1 more source

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. [PDF]

, 1987
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals.
Bordignon, C, Eglitis, MA, Gillio, AP, Kantoff, PW, Karson, E, Kernan, NA, Kohn, DB, McLachlin, JR, Moen, RC, Yu, SF   +9 more
core