Results 61 to 70 of about 66,823 (327)

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias, Heinzle, Elmar, Peifer, Susanne, Schneider, Konstantin, Volmer, Dietrich A., Zimmet, Sarah   +5 more
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Immunosuppressants and risk of Parkinson disease [PDF]

, 2018
We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use ...
Camacho-Soto, Alejandra, Gross, Anat, Nielsen, Susan Searles, Racette, Brad A, Vouri, Scott Martin, Willis, Allison W   +5 more
core   +2 more sources

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Genotoxicity and mutagenicity of inosine pranobex [PDF]

Journal of Veterinary Research, 2018
Abstract Introduction Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide. In humans, the drug is approved for the treatment of viral infections, and it might also have therapeutic use in animals ...
Jerzy Jan Jaroszewski, Andrzej K. Siwicki, Sylwia Terpiłowska, Sylwia Tobólska   +3 more
openaire   +4 more sources

Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]

, 1990
The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna, Adkison, Eiseman, Granger, Green, Hanks, Hoffee, James T. Snyder, Kamada, Kamiike, Kamiike, Kizaki, Lanir, Lee, Lee, LeMasters, LeMasters, Leonard Makowka, Marotto, Marubayashi, Marubayashi, McCord, Nishida, Parks, Prakash N. Rao, Randy S. Rubin, Rubio, Teperman, Thomas E. Starzl, Thomas R. Walsh, Thomas Weber, Turner, Van Thiel   +32 more
core   +1 more source

A Microtitre Plate Dilution Method for Minimum Killing Concentration Is Developed to Evaluate Metabolites-Enabled Killing of Bacteria by β-lactam Antibiotics

Frontiers in Molecular Biosciences, 2022
Because, as of yet, there are few new antibiotics active against multidrug-resistant bacteria are being explored, compounds including metabolites that might help us tide over this crisis are greatly expected.
Jian-jun Tao, Juan-juan Xiang, Ming Jiang, Su-fang Kuang, Xuan-xian Peng, Xuan-xian Peng, Hui Li, Hui Li   +7 more
doaj   +1 more source

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake [PDF]

, 2013
It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol.
Al-Salabi, Barrett, Biebinger, Bray, Bridges, Burchmore, Burkard, Carter, Carter, Carter, Chitanga, Collar, Damper, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, Delespaux, Delespaux, Delespaux, Delespaux, Eisler, Fulton, Geerts, Girgis-Takla, Gould, Hawking, Henriques, Hirumi, Lourie, Mamoudou, Matovu, Matovu, Moti, Mäser, Natto, Räz, Sanchez, Sanchez, Sanchez, Spoerri, Tamura, Teka, Wallace, Witola   +47 more
core   +1 more source

ADAR enzyme and miRNA story: A nucleotide that can make the difference [PDF]

, 2013
Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the biological consequence of ADAR enzyme activity is an A/G conversion within RNA molecules.
Alisi, A, Bonamassa, B, Gallo, A., Locatelli, F, Nobili, V, Tomaselli, S   +5 more
core   +2 more sources

Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma

Metabolites, 2021
In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling, Nadine Knutti, Franziska Scherr, Jörg Geiger, Juliane Weikert, Michael Rose, Roland Jahns, Uta Ceglarek, André Scherag, Michael Kiehntopf   +9 more
doaj   +1 more source