Results 61 to 70 of about 86,294 (302)

Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Frontiers in Microbiology
BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Chunhai Ke, Lanman Xu, Lanman Xu   +14 more
doaj   +1 more source

Caenorhabditis elegans Predation on Bacillus anthracis: Decontamination of Spore Contaminated Soil with Germinants and Nematodes

Frontiers in Microbiology, 2018
Remediation of Bacillus anthracis-contaminated soil is challenging and approaches to reduce overall spore levels in environmentally contaminated soil or after intentional release of the infectious disease agent in a safe, low-cost manner are needed.
Bettina Schelkle, Young Choi, Leslie W. Baillie, William Richter, Fatih Buyuk, Elif Celik, Morgan Wendling, Mitat Sahin, Theresa Gallagher   +8 more
doaj   +1 more source

Structural effects of inosine substitution in telomeric DNA quadruplex

Frontiers in Chemistry
The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s).
Ya Ying Zheng, Ya Ying Zheng, Ricky Dartawan, Ricky Dartawan, Yuhan Wu, Yuhan Wu, Chengze Wu, Chengze Wu, Hope Zhang, Hope Zhang, Jeanne Lu, Jeanne Lu, Ashley Hu, Ashley Hu, Sweta Vangaveti, Jia Sheng, Jia Sheng   +16 more
doaj   +1 more source

The formation of flavoring characteristics of meat products by changing the chemical composition of food compositions

Теория и практика переработки мяса, 2020
The article presents the results of the study of changes in flavour characteristics when using corrective additives. Monosodium glutamate, ribotide, yeast extract and hydrolysate of vegetable soy protein were used as flavoring additives (FA).
A. N. Ivankin, N. L. Vostrikova, O. N. Krasulya, E. V. Kazakova, A. V. Kulikovskii, A. S. Knyazeva   +5 more
doaj   +1 more source

Structural and functional effects of inosine modification in mRNA

RNA: A publication of the RNA Society
Inosine (I), resulting from the deamination of adenosine (A), is a prominent modification in the human transcriptome. The enzymes responsible for the conversion of adenosine to inosine in human mRNAs are the ADARs (adenosine deaminases acting on RNA ...
Herra G. Mendoza, Peter A Beal
semanticscholar   +1 more source

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study

Cancer Medicine
Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li   +6 more
doaj   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]

, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana, Gallo, Angela, Keegan, Liam P., Mannion, Niamh, O'Connell, Mary A.   +4 more
core   +2 more sources

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source