Results 81 to 90 of about 66,823 (327)

Single-Step Charge Transport through DNA over Long Distances [PDF]

, 2011
Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N_2-cyclopropyl ...
Barton, Jacqueline K., Genereux, Joseph C., Wuerth, Stephanie M.   +2 more
core   +2 more sources

Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]

, 2020
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro, Camandola, Simonetta, Cutler, Roy G., Feldman, Neil H., Haran, James B., Mattsona, Mark P., Seon Yoon, Jeong   +6 more
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents

Molecular Psychiatry, 2018
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma
Xinyu Zhou, Lanxiang Liu, Xinghui Lan, D. Cohen, Yuqing Zhang, A. Ravindran, Shuai Yuan, P. Zheng, D. Coghill, Lining Yang, S. Hetrick, Xiaofeng Jiang, J. Benoliel, A. Cipriani, P. Xie   +14 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma

Frontiers in Oncology, 2022
Pancreatic ductal adenocarcinoma presents a 5-year overall survival rate of 11%, placing an imperative need for the discovery and application of innovative treatments.
Erika Y. Faraoni, Lincoln N. Strickland, Baylee J. O’Brien, Joseph F. Barraza, Nirav C. Thosani, Curtis J. Wray, Tingting W. Mills, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg   +9 more
doaj   +1 more source

Performance of the Roche Total Mycophenolic Acid® assay on the Cobas Integra 400®, Cobas 6000® and comparison to LC-MS/MS in liver transplant patients [PDF]

, 2011
Background: Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients.
Decavele, An-Sofie, FAVOREEL, NIELS, VANDER HEYDEN, FIEN, Verstraete, Alain   +3 more
core   +1 more source

Adenosine‐to‐inosine RNA editing [PDF]

WIREs Systems Biology and Medicine, 2009
AbstractRibonucleic acid (RNA) editing is a mechanism that generates RNA and protein diversity, which is not directly encoded in the genome. The most common type of RNA editing in vertebrates is the conversion of adenosine to inosine in double‐stranded RNA which occurs in the higher eukaryotes.
Kazuko Nishikura, Boris Zinshteyn
openaire   +3 more sources

Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study presents engineered probiotics that convert immunosuppressive adenosine into inosine in tumors, alleviating immunosuppression and enhancing antitumor immunity. Demonstrating efficacy in murine ectopic and orthotopic tumor models, this approach offers a promising probiotic‐based cancer immunotherapy strategy, highlighting the potential of ...
Jinhui Wang, Jing Wang, Zhijie Yu, Hongyu Wen, Chensi Zhao, Jiayong Zhong, Chuanle Xiao, Yingqiu Li, Jianqiao Xu, Jinquan Wang, Zong‐Wan Mao, Wei Xia   +11 more
wiley   +1 more source

Variation of Meat Quality and Relationship to Gut Microbiota Among Different Pig Breeds. [PDF]

Microb Biotechnol
Our results indicated the quality of Jinhua pigs was superior to Duroc × Berkshire × Jiaxinghei pigs and Duroc × Landrace × Yorkshire pigs, and the difference in meat quality was related to the abundance of fibre‐degrading bacteria. ABSTRACT Meat production is of great importance to the world's food supply and economic development, and meat quality ...
Zhang Q, Du M, Wei S, Zhu L, Yan R, Jin M, Wang Y.   +6 more
europepmc   +2 more sources