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Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol [PDF]
D-chiroinositol (DCI) is one of the 9 inositol isomers that forms inositol phosphoglycans, which are mediators of the action of insulin. The metabolism of DCI and myo-inositol (MI) is impaired against the background of insulin resistance, including the ...
Olga A. Gromova+4 more
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Scientific Opinion on the safety and efficacy of inositol as a feed additive for fish, dogs and cats [PDF]
Inositol is an essential micronutrient for salmon, carp, tilapia and shrimps, particularly juveniles. This conclusion is extended to all fish and crustaceans.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
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Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation
Pregnancy is a complex process, featuring several necessary changes in women’s physiology. Most women undergo healthy pregnancies; even so, several women experience reduced fertility or pathologies related to the pregnancy. In the last years, researchers
Riccardo Gambioli+4 more
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Inositol pyrophosphates (PP-InsPs) comprise an important group of intracellular, diffusible cellular signals that a wide range of biological processes throughout the yeast, plant, and animal kingdoms.
Stephen B. Shears, Huanchen Wang
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The inositol polyphosphate-5-phosphatase E (Inpp5e) gene is located on chromosome 9q34.3. The enzyme it encodes mainly hydrolyzes the 5-phosphate groups of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5) P3) and phosphatidylinositol (4,5 ...
Huixuan Yue+15 more
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Inositol supplementation - known and possible applications
Introduction: Myo-inositol (MYO) and D-chiro-inositol are chemical compounds known to exert an impact on multiple signaling pathways of a human body. Due to its effects on insulin metabolism and ovaries’ hormone activity their use in polycystic ovary ...
Aleksandra Swora+9 more
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Transition behavior of the seizure dynamics modulated by the astrocyte inositol triphosphate noise [PDF]
Epilepsy is a neurological disorder with recurrent seizures of complexity and randomness. Until now, the mechanism of epileptic randomness has not been fully elucidated. Inspired by the recent finding that astrocyte GTPase-activating protein (G-protein)-coupled receptors could be involved in stochastic epileptic seizures, we proposed a neuron-astrocyte
arxiv +1 more source
Inositols in Insulin Signaling and Glucose Metabolism [PDF]
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
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Objective Invertebrates are productive models for understanding how inflammation, metabolism and aging are intertwined. We have deployed a dsRNA library screen to search for genes in Drosophila melanogaster—and hence identify human orthologs—that encode ...
Eui Jae Sung, Stephen B. Shears
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The purpose of this note is to give some corrections for our published article in [1].
José Ignacio López-Sánchez+2 more
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