Results 181 to 190 of about 582,708 (219)

Inositol 1,4,5-Trisphosphate and Its Receptors

Advances in Experimental Medicine and Biology, 2012
Activation of cells by many extracellular agonists leads to the production of inositol 1,4,5-trisphosphate (IP₃). IP₃ is a global messenger that easily diffuses in the cytosol. Its receptor (IP₃R) is a Ca(2+)-release channel located on intracellular membranes, especially the endoplasmic reticulum (ER).
Jan Parys
exaly   +3 more sources

Inositol-1,4,5-trisphosphate receptors in the vertebrate retina

Current Eye Research, 1993
Evidence has shown an activation of phosphatidylinositol 4,5-bisphosphate (PIP2) specific phospholipase C (PtdIns-PLC) by light in the vertebrate retina and rod outer segments (ROS), suggesting important roles for its two metabolites, 1,2-diacylglycerol (DG) and inositol-1,4,5-trisphosphate [Ins(1,4,5)P3].
Robert Anderson
exaly   +3 more sources

Regulation of Inositol 1,4,5-Trisphosphate Receptors

Journal of Experimental Biology, 1993
ABSTRACT Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] is a soluble second messenger responsible for the generation of highly organized Ca2+ signals in a variety of cell types. These Ca2+ signals control many cellular responses, including cell growth, fertilization, smooth muscle contraction and secretion.
I C, Marshall, C W, Taylor
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The inositol 1,4,5-trisphosphate (InsP3) receptor

The Journal of Membrane Biology, 1995
In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for ...
I, Bezprozvanny, B E, Ehrlich
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Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor

Neuropharmacology, 1995
Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in neuronal function. Some neurotransmitters produce the second messenger InsP3 which activates an intracellular calcium channel (InsP3 receptor) usually located in the endoplasmic reticulum.
F, Michelangeli, M, Mezna, S, Tovey, L G, Sayers   +3 more
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The inositol 1,4,5-trisphosphate receptors

Cell Calcium, 2005
The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals.
openaire   +2 more sources

Molecular properties of inositol 1,4,5-trisphosphate receptors

Cell Calcium, 1999
The receptors for the second messenger inositol 1,4,5-trisphosphate (IP3) constitute a family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three different gene products (types I-III) have been isolated, encoding polypeptides which assemble as large tetrameric structures.
S, Patel, S K, Joseph, A P, Thomas
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Calcium regulation of inositol 1,4,5-trisphosphate receptors

Cell Calcium, 2005
Ca2+ exerts both a stimulatory and inhibitory effect on type-I IP3R channel activity. However, the structural determinants of Ca2+ sensing in IP3Rs are not fully understood. Previous studies by others have identified eight domains of the type-I IP3R that bind 45Ca2+ when expressed as GST-fusion proteins.
Suresh K, Joseph, Samuel, Brownell, M Tariq, Khan   +2 more
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Inositol 1,4,5-Trisphosphate Receptors and Calcium Signaling

Critical Reviews™ in Neurobiology, 1996
Many cellular responses to extracellular stimuli are mediated by the second messenger inositol 1,4,5-trisphosphate (InsP3). InsP3 releases Ca2+ from intracellular stores by binding to an InsP3 receptor (InSP3R), which is an InsP3-gated Ca2+ release channel.
T, Michikawa, A, Miyawaki, T, Furuichi, K, Mikoshiba   +3 more
openaire   +2 more sources

Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators

Annual Review of Biochemistry, 2004
▪ Abstract  The inositol 1,4,5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well
Randen L, Patterson, Darren, Boehning, Solomon H, Snyder   +2 more
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