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A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
Science, 2007Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes.
Sashidhar, Mulugu +8 more
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Planta, 2023
The IPK1 genes, which code for 2-kinases that can synthesize Ins(1,2,4,5,6)P5 from Ins(1,4,5,6)P4, are expressed throughout cotton plants, resulting in the highest Ins(1,2,4,5,6)P5 concentrations in young leaves and flower buds. Cotton leaves contain large amounts of Ins(1,2,4,5,6)P5 and InsP6 compared to plants not in the Malvaceae family.
Brian Q. Phillippy +5 more
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The IPK1 genes, which code for 2-kinases that can synthesize Ins(1,2,4,5,6)P5 from Ins(1,4,5,6)P4, are expressed throughout cotton plants, resulting in the highest Ins(1,2,4,5,6)P5 concentrations in young leaves and flower buds. Cotton leaves contain large amounts of Ins(1,2,4,5,6)P5 and InsP6 compared to plants not in the Malvaceae family.
Brian Q. Phillippy +5 more
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Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium
Nature, 1990Although myo-inositol hexakisphosphate (InsP6; phytate) is the most abundant inositol phosphate in nature and probably has a wide variety of functions, neither the route of its synthesis from myo-inositol nor its metabolic relationships with other inositol-containing compounds (such as the second messenger inositol 1,4,5-trisphosphate, Ins(1,4,5)P3 ...
L R, Stephens, R F, Irvine
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Multitarget Activities of Inositol and Inositol Hexakisphosphate
2020Multiple health beneficial effects have been shown for inositol hexakisphosphate (IP6) and its parent compound myo-inositol (Ins) in animal and human studies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades.
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Internalization and distribution of inositol hexakisphosphate in red blood cells
Biotechnology and Applied Biochemistry, 1996Inositol hexakisphosphate (InsP6), an allosteric effector of haemoglobin, is able to modify the oxyhaemoglobin dissociation curve. The rightwards shift of the curve increases the in vivo oxygen delivery to tissues. Such an exogenous substance may be internalized into red blood cells (RBC) using a reversed lysisâresealing process following a hypoosmotic
L, Boucher, M, Chassaigne, C, Ropars
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Membrane-associated inositol hexakisphosphate binding in bovine retina
Current Eye Research, 1995We investigated the InsP6 binding proteins in bovine retinal membranes and rod outer segments (ROS) by radioligand binding assay and western blotting. The relative affinity of InsP6 for the binding protein was determined by competitive binding of [3H]-InsP6 with increasing concentrations of the unlabeled InsP6 or other isomers. InsP6 specifically binds
N S, Day, A J, Ghalayini, R E, Anderson
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A Femtomole-Sensitivity Mass Assay for Inositol Hexakisphosphate
2010Inositol hexakisphosphate (InsP(6)) is an important component of cells, and its mass levels are usually assayed by either (a) equilibrium labelling of cell cultures with radiolabelled inositol or (b) by a variety of mass assays of differing sensitivities and ambiguities. Here, we describe a mass assay for InsP(6) that is based on phosphorylating InsP(6)
Andrew J, Letcher +2 more
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Neuronal cytotoxicity of inositol hexakisphosphate (phytate) in the rat hippocampus
Brain Research, 1996D-myo-Inositol hexakisphosphate (InsP6, phytate), a normal cellular constituent, was found to be toxic to neuronal perikarya when injected into the rat hippocampus. However, the extrinsic cholinergic innervation of the hippocampus (as estimated by staining for acetylcholinesterase) was unaffected.
G J, Lees, W, Leong
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Interaction of myo-inositol hexakisphosphate with biogenic and synthetic polyamines
Organic & Biomolecular Chemistry, 2015myo-Inositol hexakisphosphate (phytate) forms very stable adducts with biogenic and synthetic polyamines in aqueous solution.
Julia, Torres +4 more
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Adsorption-Desorption of Myo-Inositol Hexakisphosphate on Hematite
Soil Science, 2014Adsorption, desorption, and precipitation reactions at environmental interfaces impact the bioavailability, mobility, and fate of organic phosphates in terrestrial and aquatic environments. Myo-inositol hexakisphosphate (IHP) is the most abundant organic phosphate in soils.
Yupeng Yan +5 more
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