Assessing the omnipotence of inositol hexakisphosphate [PDF]
Cellular Signalling, 2001 This review assesses the authenticity of inositol hexakisphosphate (InsP(6)) being a wide-ranging regulator of many important cellular functions. Against a background in which the possible importance of localized InsP(6) metabolism is discussed, there is the facile explanation that InsP(6) is merely an "inactive" precursor for the diphosphorylated ...
Stephen B Shears
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Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins. [PDF]
PLoS Pathogens, 2010 Large bacterial protein toxins autotranslocate functional effector domains to the eukaryotic cell cytosol, resulting in alterations to cellular functions that ultimately benefit the infecting pathogen.
Martina Egerer, Karla J F Satchell
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How HIV-1 Uses the Metabolite Inositol Hexakisphosphate to Build Its Capsid [PDF]
VirusesThe HIV-1 capsid is one of virology’s most iconic structures, yet how it assembles has long remained elusive. Remarkably, the capsid is made from just a single protein, CA, which forms a lattice of ~250 hexamers and exactly 12 pentamers.
Leo C. James
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Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication [PDF]
mBioWe have investigated the function of inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5) in the replication of murine leukemia virus (MLV).
Banhi Biswas +7 more
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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats [PDF]
Advances in Pharmacological Sciences, 2019 This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats.
Shadae R. Foster +4 more
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Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening. [PDF]
ACS Pharmacol Transl Sci, 2021 Liao G +12 more
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Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis. [PDF]
Cell Mol Life Sci, 2022 AbstractEndocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood. We now show that syndapin I/PACSIN 1 is expressed in pancreatic β cells and that its knockdown abrogates β cell endocytosis leading to disturbed plasma membrane protein homeostasis ...
Shi Y +9 more
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The Inositol Hexakisphosphate Kinase Family [PDF]
Journal of Biological Chemistry, 2000 The inositol pyrophosphate disphosphoinositol pentakisphosphate (PP-InsP(3)/InsP(7)) is formed in mammals by two recently cloned inositol hexakiphosphate kinases, InsP(6)K1 and InsP(6)K2 (Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., and Snyder, S. H. (1999) Curr. Biol. 9, 1323-1326).
Adolfo Saiardi +3 more
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Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates
Frontiers in Plant Science, 2022 Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer +7 more
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Nature Communications, 2022 Uba6 is an E1 enzyme that regulates numerous cellular processes by activating ubiquitin and FAT10 pathways. Here, the authors present crystal structures that illuminate Uba6 catalytic mechanisms and reveal inositol hexakisphosphate as a cofactor that ...
Lingmin Yuan +15 more
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