Results 11 to 20 of about 2,887 (163)

Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening [PDF]

ACS Pharmacology and Translational Science, 2021
Wenjuan Ye, Robert K Harmel, Dorothea Fiedler   +2 more
exaly   +2 more sources

Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes [PDF]

Journal of Biological Chemistry
Miriam L Greenberg
exaly   +2 more sources

A Legionella effector kinase is activated by host inositol hexakisphosphate. [PDF]

J Biol Chem, 2020
ABSTRACT The transfer of a phosphate from ATP to a protein substrate, a modification known as phosphorylation, is catalyzed by protein kinases. Protein kinases play a crucial role in virtually every cellular activity.
Sreelatha A, Nolan C, Park BC, Pawłowski K, Tomchick DR, Tagliabracci VS.   +5 more
europepmc   +4 more sources

The Inositol Hexakisphosphate Kinase Family [PDF]

Journal of Biological Chemistry, 2000
The inositol pyrophosphate disphosphoinositol pentakisphosphate (PP-InsP(3)/InsP(7)) is formed in mammals by two recently cloned inositol hexakiphosphate kinases, InsP(6)K1 and InsP(6)K2 (Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., and Snyder, S. H. (1999) Curr. Biol. 9, 1323-1326).
Adolfo Saiardi, James J. Caffrey, Solomon H. Snyder, Stephen B. Shears   +3 more
openaire   +4 more sources

Inositol hexakisphosphate increases the size of platelet aggregates. [PDF]

Biochem Pharmacol, 2019
The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP6 concentration upon ...
Brehm MA, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch BH, Riley AM, Mayr GW, Potter BVL, Windhorst S.   +12 more
europepmc   +5 more sources

Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates

Frontiers in Plant Science, 2022
Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer, Naga Jyothi Pullagurla, Ranjana Yadav, Priyanshi Rana, Henning J. Jessen, Marília Kamleitner, Gabriel Schaaf, Debabrata Laha   +7 more
doaj   +1 more source

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Nature Communications, 2022
Uba6 is an E1 enzyme that regulates numerous cellular processes by activating ubiquitin and FAT10 pathways. Here, the authors present crystal structures that illuminate Uba6 catalytic mechanisms and reveal inositol hexakisphosphate as a cofactor that ...
Lingmin Yuan, Fei Gao, Zongyang Lv, Digant Nayak, Anindita Nayak, Priscila dos Santos Bury, Kristin E. Cano, Lijia Jia, Natalia Oleinik, Firdevs Cansu Atilgan, Besim Ogretmen, Katelyn M. Williams, Christopher Davies, Farid El Oualid, Elizabeth V. Wasmuth, Shaun K. Olsen   +15 more
doaj   +1 more source

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

Molecules, 2020
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee, Min-Gyu Kim, Hyoungjoon Ahn, Seyun Kim   +3 more
doaj   +1 more source

Inositol Phosphates and Retroviral Assembly: A Cellular Perspective

Viruses, 2021
Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
doaj   +1 more source

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly

Viruses, 2021
The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles.
Martin Obr, Florian K. M. Schur, Robert A. Dick   +2 more
doaj   +1 more source