Results 31 to 40 of about 6,478 (207)

A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity [PDF]

, 2011
We previously identified the lpa1 (low phytic acid) 280-10 line that carries a mutation conferring a 90% reduction in phytic acid (InsP6) content. In contrast to other lpa mutants, lpa1(280-10) does not display negative pleiotropic effects.
Bollini, Roberto, Brearley, Charles A., Campion, Bruno, Cassani, Elena, Doria, Enrico, Forti, Luca, Nielsen, Erik, Panzeri, Dario, Pilu, Roberto, Sparvoli, Francesca, Tagliabue, Giovanni   +10 more
core   +1 more source

Inositol hexakisphosphate kinase 1 (IP6K1) regulates inositol synthesis in mammalian cells [PDF]

The FASEB Journal, 2016
myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Wenxi, Yu, Cunqi, Ye, Miriam L, Greenberg   +2 more
openaire   +2 more sources

Role of Inositols and Inositol Phosphates in Energy Metabolism

Molecules, 2020
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree, Nanthaphop Thongmaen, Kwanchanit Tantivejkul, Chantacha Sitticharoon, Ivana Vucenik   +4 more
doaj   +1 more source

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]

, 2014
Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin sensitivity, β-cell dysfunction, and elevated hepatic glucose production.
Elliott, B.T., Elliott, B.T., Mackenzie, R.W.A., Mackenzie, R.W.A.   +3 more
core   +4 more sources

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]

, 2016
Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC, Crocco, P, Maletta, R, Passarino, G, Rose, G, Saiardi, A, Wilson, MS   +6 more
core   +1 more source

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging ...
Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun   +12 more
doaj   +1 more source

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function [PDF]

, 2017
Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks) comprise a family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.
Afonine, Alcázar-Roman, Angulo, Barker, Baños-Sanz, Berridge, Boularan, Brehm, Brehm, Byrum, Caddick, Chakraborty, Cheek, Cowtan, DeLano, Emsley, Evans, Finn, Franco-Echevarria, González, González, Gosein, Gosein, Gosein, Gouet, Gouy, Holm, Holmes, Irvine, Juanhuix, Kabsch, Laskowski, Li, Macbeth, McCoy, Murshudov, Onnebo, Ouyang, Panjikar, Phillippy, Phillippy, Qian, Saiardi, Scherer, Shears, Shears, Stephens, Sweetman, Terwilliger, Terwilliger, Vagin, Verbsky, Verbsky, Wang, Wang, Winn   +55 more
core   +1 more source

Protein pyrophosphorylation: moving forward [PDF]

, 2016
Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core   +3 more sources

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2 [PDF]

Proceedings of the National Academy of Sciences, 2010
Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death. The tumor suppressor p53 responds to genotoxic stress by engaging a transcriptional program leading to cell ...
Koldobskiy, MA Koldobskiy, Michael A., Chakraborty, A Chakraborty, Anutosh, Werner, JK Werner, J. Kent, Jr., Snowman, AM Snowman, Adele M., Juluri, KR Juluri, Krishna R., Vandiver, MS Vandiver, M. Scott, Kim, S Kim, Seyun, Heletz, S Heletz, Shira, Snyder, SH Snyder, Solomon H.   +8 more
openaire   +2 more sources