Results 131 to 140 of about 30,835 (333)
Andrology, EarlyView.Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández +9 more
wiley +1 more source
The investigation of antinutritional factors in Phaseolus vulgaris. Environmental and varietal differences [PDF]
Biotechnologie, Agronomie, Société et Environnement, 1999 This study enables us to indicate that the oligosaccharide raffinose family, phytate, saponin and lectin contents of P. vulgaris are clearly influenced by both environmental and genetics factors.
Burbano C. +4 more
doaj
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
A segment of the C-terminal half of the G-protein .31 subunit specifies its interaction with the γ4 subunit [PDF]
, 1995 The β and γ subunits of the heterotrimeric guanine nucleotide binding (G protein) act as a dimer and directly regulate various signal transduction pathways.
Katz, Arieh, Simon, Melvin I.
core
A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto +12 more
wiley +1 more source
A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut [PDF]
, 2014 Régis Stentz +11 more
openalex +1 more source
C-Alkyl inositol phosphates for use in receptor-ligand engineering
, 2009 The phosphatidylinositol phosphates (PIPns) and inositol phosphates (IPns) are intricately involved in cell signalling. They bind to a vast array of proteins, which results in a host of physiological responses.
Swarbrick, Joanna, Swarbrick, Joanna
core +1 more source
Cell Proliferation, EarlyView.During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi +7 more
wiley +1 more source
Polar group exchange receptor-ligand engineering of protein kinase B's pleckstrin homology domain
, 2010 A diverse range of cellular functions are influenced by the activity of protein kinase B (PKB, also known as Akt). PKB is involved in a number of physiological pathways, perturbation of which can lead to pathological conditions.
Cooper, Samuel John, Cooper, Samuel John
core +1 more source