Results 71 to 80 of about 14,137 (280)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Simultaneous HPLC determination of soluble signaling molecules and metabolic status in neuroblastoma cell cultures

Physiological Reports
Several laboratories have explored the capacity of the anion exchange chromatography method in evaluating distinct forms of inositol phosphates in a single analytical process.
Natalie Chaves Ferreira, Chiara Gatnau‐Civardi, Miquel Riera‐Codina   +2 more
doaj   +1 more source

Beyond phytic acid: Nutrigenetic and nutrigenomic insights into its hydrolysis, transport, and metabolism

Journal of Agriculture and Food Research
Phytic acid (inositol hexakisphosphate, IP6), often known as an antinutrient for its mineral-chelating properties, has emerged as a precursor to bioactive metabolites with significant health roles.
Suyun Choi, Sangyong Choi
doaj   +1 more source

Signalling Properties of Inositol Polyphosphates

Molecules, 2020
Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new insights into their cellular ...
Tania Maffucci, Marco Falasca
doaj   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Characterization of the Inositol Monophosphatase Gene Family in Arabidopsis

Frontiers in Plant Science, 2015
Synthesis of myo-inositol is crucial in multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. The myo-inositol monophosphatase (IMP) enzyme is required for the synthesis of myo-inositol, breakdown of
Aida eNourbakhsh, Eva eCollakova, Glenda E Gillaspy   +2 more
doaj   +1 more source

Urochloa ruziziensis cover crop increases the cycling of soil inositol phosphates [PDF]

, 2018
Ruzigrass (Urochloa ruziziensis) is a cover crop that is commonly used in Brazil and exudes high concentrations of organic acids from its roots, and is therefore expected to mobilize soil organic P such as inositol phosphates. However, it is not known if
Rosolem, C.A., Wearing, Catherine, Haygarth, P.M., Haygarth, Philip M., Rosolem, Ciro A., Almeida, Danilo S., Almeida, Danilo S. [UNESP], Menezes-Blackburn, Daniel, Turner, Benjamin L., Wearing, C., Rosolem, Ciro A. [UNESP], Menezes-Blackburn, D.   +11 more
core   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

A Chiral Phosphoramidite Reagent for the Synthesis of Inositol Phosphates

, 2016
There is a paucity of chiral phosphoramidite reagents or chiral catalysis methods for the synthesis of biologically relevant inositol phosphates. A new C2-symmetrical chiral phosphoramidite has been developed and successfully applied to the synthesis of ...
Bastien Castagner (1749490), Estelle Durantie (2849273), Samuel Huwiler (2849276), Jean-Christophe Leroux (548966)   +3 more
core   +1 more source