Results 81 to 90 of about 14,137 (280)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Inositol Phosphates and their Biological Effects

, 2020
The paper is dedicated to data analysis on inositol phosphates nature distribution, structure and biological functions as well as enzymes - phytases - capable to hydrolyze these hardly digestible compounds and their complexes.
Suleimanova A., Chastukhina I., Valeeva L., Balaban N., Sharipova M.   +4 more
core  

Diphosphosinositol Polyphosphates and Energy Metabolism: Assay for ATP/ADP Ratio

, 2010
Several inositol compounds undergo rapid cycles of phosphorylation and dephosphorylation. These cycles at.: dependent on ATP and energy metabolism. Therefore, interfering with the cellular energy metabolism can change the concentration of rapidly turning
Barker, Christopher J., Andreas Nagel, Barker, CJ, Berggren, P-O, Illies, C,, Christopher Illies, Nagel, Andreas, Iilies, Christopher, Berggren, Per-Olof, Per-Olof Berggren, Nagel, A, Christopher J. Barker   +11 more
core   +1 more source

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, EarlyView.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Synthetic Pores as Sensors: Focus on Zinc Filters for IP7 and Phytate Contents in Lentils, Almonds, and Soybeans

CHIMIA, 2008
Recent experimental evidence confirms synthetic pores as operational multicomponent sensors in complex matrices. This work in practice is summarized, with emphasis on topics of current concern which exemplify the use of enzymes as signal ...
Sara M. Butterfield, Stefan Matile
doaj   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer

Frontiers in Oncology, 2017
Calcium is a critical regulator of cell death pathways. One of the most proximal events leading to cell death is activation of plasma membrane and endoplasmic reticulum-resident calcium channels.
Jessica J. Chen, Darren Boehning
doaj   +1 more source

myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei

, 2012
myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via ...
Gonzalez-Salgado, A., Bütikofer, P., Monika Rauch, Pascal Mäser, Rauch, Monika, Sigel, Erwin, Erwin Sigel, Greganova, Eva, Steinmann, M. E., Mäser, Pascal, Bütikofer, Peter, Rauch, M., Sigel, E., Michael E. Steinmann, Mäser, P., Amaia Gonzalez-Salgado, Gonzalez-Salgado, Amaia, Steinmann, Michael E, Eva Greganova, Peter Bütikofer, Greganova, E.   +20 more
core   +1 more source