Results 121 to 130 of about 2,351 (231)

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry [PDF]

, 2021
Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence of at least one energetic pyrophosphate moiety on the myo-inositol ring.
Eisenbeis, VB, Jessen, HJ, Qiu, D, Saiardi, A   +3 more
core  

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. [PDF]

, 2014
Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of ...
Andres Obregón‐Henao, Angeleen Fleming, Beate Kampmann, Benard EL, Catherine Klapholz, David C Rubinsztein, Diane J Ordway, Joseph Burgon, Karen Brown, Karen E Anderson, Katherine M Henry, Krisztina Hegyi, Lucy Hepburn, Marcela Henao Tamayo, Mark Schiebler, Maurizio Renna, Phillip T Hawkins, Randall Basaraba, Robert R Kay, Rodrigo Andres Floto, Sandra M Newton, Sarah Coulter, Stephen A Renshaw   +22 more
core   +3 more sources

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +1 more source

Inositol biosynthesis is fine‐tuned by inositol pyrophosphates in Saccharomyces cerevisiae

The FASEB Journal, 2013
In yeast , inositol biosynthesis is coordinated with the synthesis of phospholipids by controlling the expression of enzymes in the biosynthetic pathways. Inositol pyrophosphates, most recently characterized in the inositide family, have diverse roles in phosphate signaling and other ...
Cunqi Ye, Miriam L Greenberg
openaire   +1 more source

Phosphate-activated cyclin-dependent kinase stabilizes G1 cyclin to trigger cell cycle entry [PDF]

, 2016
G1 cyclins, in association with a cyclin-dependent kinase (CDK), are universal activators of the transcriptional G1-S machinery during entry into the cell cycle.
Aldea, Marti, Bru, Samuel, Cloteta, J., Escoté, Xavier, Hernández-Ortega, Sara, Menoyo, Sandra, Ricco, Natalia   +6 more
core   +1 more source

Inositol Pyrophosphates and Phosphate Sensing in Plants

The FASEB Journal, 2019
Phosphate (P i ) is an essential nutrient for plants, required for plant growth and seed viability. Under P i stress, plants undergo dynamic changes to leverage available P i .
Glenda Gillaspy, Olusegun Adepoju, Eric Land, Sarah Phoebe Williams, Janet Donahue, Caitlin Cridland, Catherine Freed, Imara Perera   +7 more
openaire   +1 more source

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues. [PDF]

Chem Sci, 2023
Qiu D, Gu C, Liu G, Ritter K, Eisenbeis VB, Bittner T, Gruzdev A, Seidel L, Bengsch B, Shears SB, Jessen HJ.   +10 more
europepmc   +1 more source

Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis [PDF]

, 2016
Blood coagulation leading to fibrin formation is essential to prevent loss of blood (hemostasis), but can also contribute to occlusion of vessels (thrombosis).
Labberton, Linda
core   +1 more source

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis [PDF]

, 2021
Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Borghi, F, Desfougères, Y, Fiedler, D, Harmel, RK, Jessen, HJ, Livermore, TM, Portela-Torres, P, Qiu, D, Saiardi, A   +8 more
core  

Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae

Biomolecules
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Ileana Cornelia Farcasanu   +2 more
doaj   +1 more source