Protein Glycosylation Patterns Shaped by the IRE1‐XBP1s Arm of the Unfolded Protein Response
Abstract The unfolded protein response (UPR) is a sensing and signaling pathway that surveys the endoplasmic reticulum (ER) for protein folding challenges and responds whenever issues are detected. UPR activation leads to upregulation of secretory pathway chaperones and quality control factors, as well as reduces the nascent protein load on the ER ...
Kenny Chen, Matthew D. Shoulders
wiley +1 more source
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes [PDF]
Inositol phosphates and inositol pyrophosphates are small molecule metabolites that play important roles in nuclear processes such as transcription control, mRNA export and DNA repair. On this wonderful occasion of the fiftieth anniversary of the Advances in Enzyme Regulation conference, it is a privilege to participate through presenting recent ...
John D. York, Marco M. Tsui
openaire +3 more sources
Inositol pyrophosphates are cellular signals that are created by the actions of inositol kinases and are degraded by highly active inositol phosphatases.
Gayane Machkalyan+4 more
doaj
Developing Dictyostelium discoideum as a model to study the synthesis and metabolism of inositol pyrophosphates and inorganic polyphosphate [PDF]
Inositol pyrophosphates and inorganic polyphosphate (polyP) represent two of the most phosphate-rich molecules in the cell. However, the synthesis, metabolism and function of these “high-energy” molecules are not well understood.
Livermore, TM
core
The phosphate starvation response regulator PHR2 antagonizes arbuscule maintenance in Medicago
Summary Phosphate starvation response (PHR) transcription factors play essential roles in regulating phosphate uptake in plants through binding to the P1BS cis‐element in the promoter of phosphate starvation response genes. Recently, PHRs were also shown to positively regulate arbuscular mycorrhizal colonization in rice and lotus by controlling the ...
Peng Wang+7 more
wiley +1 more source
Resin acid δ13C and δ18O as indicators of intra‐seasonal physiological and environmental variability
Abstract Understanding the dynamics of δ13C and δ18O in modern resin is crucial for interpreting (sub)fossilized resin records and resin production dynamics. We measured the δ13C and δ18O offsets between resin acids and their precursor molecules in the top‐canopy twigs and breast‐height stems of mature Pinus sylvestris trees.
Yu Tang+11 more
wiley +1 more source
Fission yeast phosphate homeostasis genes are repressed in phosphate-rich medium by transcription of upstream lncRNAs that interferes with activation of the flanking mRNA promoters.
A. Garg, S. Shuman, B. Schwer
semanticscholar +1 more source
ABSTRACT Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic ...
Saseendran Shalu+5 more
wiley +1 more source
Inositol biosynthesis is fine‐tuned by inositol pyrophosphates in Saccharomyces cerevisiae
In yeast, inositol biosynthesis is coordinated with the synthesis of phospholipids by controlling the expression of enzymes in the biosynthetic pathways. Inositol pyrophosphates, most recently characterized in the inositide family, have diverse roles in phosphate signaling and other important cellular processes.
Miriam L. Greenberg, Cunqi Ye
openaire +1 more source
IP6K3 and IPMK variations in LOAD and longevity: evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival [PDF]
Several studies reported that genetic variants predisposing to neurodegeneration were at higher frequencies in centenarians than in younger controls, suggesting they might favor also longevity. IP6K3 and IPMK regulate many crucial biological functions
Bruni, AC+8 more
core