Results 41 to 50 of about 59,060 (257)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Inkuiri, 2014 The objectives of this research were to develop an Guided Inquiry Module Based on Local Potentials to Bryophyte and Pteridophyte Materials, to know feasibility an Guided Inquiry Module Based on Local Potentials to Bryophyte and Pteridophyte Materials ...
Tri - Novana, Sajidan - -, Maridi - -
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Jurnal BIOEDUIN, 2022 21st century skills are learning and innovation skills that focus on the 4Cs (collaboration, creative thinking, communication, critical thinking and problem solving, and innovation).
Sumiyati Sa’adah +2 more
doaj +1 more source
Inquiry-based Learning of Database Concepts [PDF]
2018 17th International Conference on Information Technology Based Higher Education and Training (ITHET), 2018 In many degree programs, relational database concepts and skills are taught through a combination of lectures combined with tutorials or laboratory sessions, although flipped learning approaches have recently been gaining increasing popularity.
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Project Based Learning and Invitations: A Comparison
Journal of Curriculum Theorizing, 2015 Thispaper compares two instructional approaches: project based learning andinvitations. It begins with a discussion of the definitions of project basedlearning and invitations as well as their theoretical bases.
Cheu-jey Lee
doaj +1 more source