Results 91 to 100 of about 1,121,211 (304)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

THE INFLUENCE OF INQUIRY BASED LEARNING (IBL) TOWARD SCIENCE ‎LITERATION SKILL OF STUDENTS

EDUSAINS, 2017
This research aims to determine the effect of Inquiry-Based Learning (IBL) for students grade VIII’s scientific literacy skill based on the plant tissues concept. The method used in this research is a quasi-experimental method.
Buchori Muslim, Zulfiani Zulfiani Zulfiani, Alif Luthvi Azizah   +2 more
doaj   +1 more source

A design-based study of Citizen Inquiry for geology [PDF]

, 2013
Citizen Inquiry forms a new method of informal science learning and aims to enable the engagement of citizens in online scientific investigations. Citizen Inquiry combines aspects from Citizen Science and Inquiry-based learning and is implemented through
Aristeidou, Maria, Scanlon, Eileen, Sharples, Mike   +2 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Inquiry Learning: Level, Discipline, Class Size, What Matters?

International Journal for the Scholarship of Teaching and Learning, 2011
Inquiry learning is a pedagogical approach that focuses on the processes and skills required to conduct research. It is a pedagogical approach that has been demonstrated to have positive learning outcomes.
Susan Vajoczki, Susan Watt, Michelle Vine, Rose Liao   +3 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Pengaruh Model Pembelajaran Inkuiri Terstruktur dengan Pendekatan Saintifik Terhadap Kemampuan Berpikir Kritis dan Hasil Belajar Fisika Siswa

JPFT (Jurnal Pendidikan Fisika dan Teknologi), 2017
This study aims to determine the effect of structured inquiry learning model with scientific approach on student’s critical thinking skills and physics learning outcomes of class X in SMAN 1 Gerung in academic year 2014/2015.
Lia Saptini Handriani, Ahmad Harjono, Aris Doyan   +2 more
doaj   +1 more source

How Does Leadership Matter? Developing and Teaching a Definition of Hands-On Science, a Prerequisite for Effective Inquiry Teaching [PDF]

, 2013
This descriptive case study describes leadership skills and planning for setting clear directions by program leaders for a statewide professional development initiative to extend improvement in science teaching and learning.
Sterling, D. R.
core   +1 more source

Engaging in and engaging with research: teacher inquiry and development [PDF]

, 2009
The connection between teacher inquiry, professional development and school improvement was recognised 30 years ago by Lawrence Stenhouse. Stenhouse contributed many valuable insights into the role of practitioner enquiry in creating and utilising ...
Hall, Elaine
core   +1 more source