Results 1 to 10 of about 4,048,456 (298)
Estimating the fitness effect of an insertion sequence [PDF]
Journal of Mathematical Biology, 2018 Since its discovery, mobile DNA has fascinated researchers. In particular, many researchers have debated why insertion sequences persist in prokaryote genomes and populations.
Barbour, A. +2 more
core +5 more sources
Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii. [PDF]
ISME J, 2022 We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an
Whiteway C +7 more
europepmc +2 more sources
Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria. [PDF]
Nat Commun, 2021 Insertion sequences (IS) are ubiquitous bacterial mobile genetic elements, and the mutations they cause can be deleterious, neutral, or beneficial. The long-term dynamics of IS elements and their effects on bacteria are poorly understood, including ...
Consuegra J +6 more
europepmc +2 more sources
Insertion sequence transposition inactivates CRISPR-Cas immunity. [PDF]
Nat Commun, 2023 AbstractCRISPR-Cas immunity systems safeguard prokaryotic genomes by inhibiting the invasion of mobile genetic elements. Here, we screened prokaryotic genomic sequences and identified multiple natural transpositions of insertion sequences (ISs) into cas genes, thus inactivating CRISPR-Cas defenses.
Sheng Y +9 more
europepmc +4 more sources
Microbiology and Molecular Biology Reviews, 1998 SUMMARY Insertion sequences (ISs) constitute an important component of most bacterial genomes. Over 500 individual ISs have been described in the literature to date, and many more are being discovered in the ongoing prokaryotic and eukaryotic genome-sequencing projects. The last 10 years have also seen some striking advances in
Mahillon, Jacques, Chandler, M.
openaire +3 more sources
Nature Biotechnology, 2023 Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion.
Jonas Koeppel +8 more
semanticscholar +1 more source
Insertion sequences in prokaryotic genomes [PDF]
Current Opinion in Microbiology, 2006 Insertion sequences (ISs) are small DNA segments that are often capable of moving neighbouring genes. Over 1500 different ISs have been identified to date. They can have large and spectacular effects in shaping and reshuffling the bacterial genome. Recent studies have provided dramatic examples of such IS activity, including massive IS expansion during
Patricia, Siguier +2 more
openaire +2 more sources
Insertion Sequence Diversity in Archaea [PDF]
Microbiology and Molecular Biology Reviews, 2007 SUMMARYInsertion sequences (ISs) can constitute an important component of prokaryotic (bacterial and archaeal) genomes. Over 1,500 individual ISs are included at present in the ISfinder database (www-is.biotoul.fr), and these represent only a small portion of those in the available prokaryotic genome sequences and those that are being discovered in ...
J, Filée, P, Siguier, M, Chandler
openaire +2 more sources
Everyman's Guide to Bacterial Insertion Sequences [PDF]
Microbiology Spectrum, 2015 ABSTRACT The number and diversity of known prokaryotic insertion sequences (IS) have increased enormously since their discovery in the late 1960s. At present the sequences of more than 4000 different IS have been deposited in the specialized ISfinder database. Over time it has become increasingly apparent that they are important actors in the
Siguier, Patricia +4 more
openaire +5 more sources
Insertion Sequence IS 900 Revisited [PDF]
Journal of Clinical Microbiology, 2006 ABSTRACT Many studies investigating Mycobacterium avium subsp. paratuberculosis in Crohn's disease have used molecular detection of IS 900 in clinical samples, but some have described polymorphisms in IS 900 as variants of this ...
Makeda, Semret +2 more
openaire +2 more sources