Results 41 to 50 of about 603,213 (294)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Gamified interactive e-books for bullying prevention: enhancing knowledge and motivation in Chinese primary schools

open access: yesFrontiers in Psychology
Bullying is increasingly prevalent in Chinese schools, contributing to a rise in associated criminal cases. A key factor in this trend is the lack of comprehensive understanding of bullying.
Jiawei Shao   +2 more
doaj   +1 more source

Instructional Design of Call: a Perspective of Flexibility, Learning Goal, and Computer Roles [PDF]

open access: yes, 2015
: Instructional Design of Call: A Perspective of Flexibility, Learning Goal, and Computer Roles. The purpose of this study is to review instructional design (ID) used in computer assisted language learning (CALL) studies.
Saukah, A. (Ali), Suarcaya, P. (Putu)
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Limits of Metacognitive Prompts for Confidence Judgments in an Interactive Learning Environment

open access: yesOpen Education Studies
Metacognitive activities are reported to improve learning but prompts to support metacognition have only been investigated with mixed results. In the present study, metacognitive prompts for confidence judgments were implemented in a learning platform to
Klar Maria   +2 more
doaj   +1 more source

Qualitative Content Analysis of Connectivism Theory and Introducing a Conceptual Model of Learning Ecology Design [PDF]

open access: yesInterdisciplinary Journal of Virtual Learning in Medical Sciences, 2014
Introduction: The aim of this research was to qualitatively analyze the teaching and learning components of the connectivism theory and introduce a conceptual model for designing of the connectivist learning.Materials & Methods: The method of this study ...
Eisa Rezaei   +3 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Reaching Students and Faculty: Offering Instructional Design Services In Your Library

open access: yes, 2002
This presentation is to show how libraries have changed over time and become academically responsible for more that handling books, periodicals, videos and the like. As libraries have changed and led in the area of technology on many university campuses,
Sturgeon, C. Michael
core   +1 more source

Instructional Designers' Observations about Identity, Communities of Practice and Change Agency [PDF]

open access: yes, 2004
We presume that models and theory in instructional design inform professional practice, but theory has not been consistently built from the professional experiences of instructional designers.
Campbell, Katy   +2 more
core   +2 more sources

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