Results 51 to 60 of about 595,744 (272)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Effect of the 5E Instructional Design Model on Students’ Critical Thinking in an Educational Psychology Course [PDF]
Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2014 Introduction: This study aimed to examine the effect of the 5E Instructional Design Model on critical thinking of the students taking the educational psychology course. The main hypothesis of the study was that the critical thinking level of the students
Moohamad Hasan Amirtimori +2 more
doaj
Creating Online Lessons: A Faculty Development Seminar Series [PDF]
, 2003 The World Wide Web is being used increasingly to deliver instruction in medical education. Consequently, there is a need to train faculty in developing and implementing online instruction. We developed and implemented a seminar series to teach faculty to
Reznich , PhD, Christopher +3 more
core
Designing an interactive multimedia instructional environment: the civil war interactive [PDF]
, 1993 This article describes the rationales behind the design decisions made in creating The Civil War Interactive, an interactive multimedia instructional product based on Ken Burns''s film series The Civil ...
Cates, Ward +2 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Reading & Writing, 2019 Background: Literacy education in the foundation phase is a global concern. Studies have shown that mastering literacy in the first three years of school ensured academic success and lack of it had negative effects academically, socially and economically.
Patience Dlamini, Ayub Sheik
doaj +1 more source
YOGYAKARTA (INDONESIA) EFL TEACHERS’ CONCEPTUALIZATION OF PEDAGOGICAL CONTENT KNOWLEDGE IN THEIR INSTRUCTIONAL CURRICULUM DESIGN AND PRACTICES [PDF]
, 2016 The evolving demand of teachers as effective curriculum practitioners and adapters has put the centrality of teacher knowledge in the dynamic system of instructional curriculum development. This study is aimed at exploring the development of Yogyakarta
Triastuti, Anita
core
A comparative analysis of the effects of instructional design factors on student success in e-learning: multiple-regression versus neural networks [PDF]
, 2009 This study explores the relationship between the student performance and instructional design. The research was conducted at the E-Learning School at a university in Turkey.
Cebeci, Halil Ibrahim +2 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source