Results 41 to 50 of about 485,419 (310)

Regulation of cardiac autophagy by insulin‐like growth factor 1 [PDF]

IUBMB Life, 2013
Insulin‐like growth factor‐1 (IGF‐1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF‐1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal‐regulated kinase (ERK), and phospholipase C (PLC)/inositol 1,4,5 ...
Troncoso, Rodrigo, Díaz Elizondo, Jessica, Espinoza, Sandra P., Navarro Márquez, Mario F., Oyarzún, Alejandra P., Riquelme, Jaime A., García Carvajal, Ivonne, Díaz Araya, Guillermo, García Nannig, Lorena, Hill, Joseph A., Lavandero González, Sergio   +10 more
openaire   +7 more sources

Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis

Central European Journal of Immunology, 2021
Interactions between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the immune system are complex, bidirectional, but not fully explained.
Ewelina Witkowska-Sędek, Beata Pyrżak
doaj   +1 more source

Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La enfermedad trofoblástica gestacional comprende un conjunto de patologías caracterizadas por crecimiento e invasión anómalos del trofoblasto.
Yinth Andrea Bernal, Luis Eduardo Díaz, Jinneth Acosta, Cecilia Crane, Stella Carrasco-Rodríguez, Antonio José Bermúdez, Myriam Sánchez-Gómez   +6 more
doaj   +1 more source

Insulin-Like Growth Factor-1 in Acute Ischemic Stroke

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018
Background Cerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability.
Hala Shaheen, Sayed Sobhy, Sherine El Mously, Manal Niazi, Mohammed Gomaa   +4 more
doaj   +1 more source

Relationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth

Acta Clinica Croatica, 2020
Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses.
Lidija Banjac, Jelena Kotur-Stevuljevic, Tamara Gojković, Vesna Bokan-Mirkovic, Goran Banjac, Gorica Banjac   +5 more
doaj   +1 more source

Angiopoietin-Like Protein 4 and Insulin-Like Growth Factor-1 Expression in Invasive Breast Carcinoma in Young Women

, 2022
Biomarker identification is imperative for invasive breast carcinoma, which is more aggressive and associated with higher mortality and worse prognosis in younger patients (<45 years) than in older patients (>50 years).
Lam, AK, Alaa Siddig, Wan Faiziah Wan Abdul Rahman, Yaacob, NM, Rahman, WFWA, Zaleha Kamaludin, Kamaludin, Z, Najib Majdi Yaacob, Alfred K. Lam, Siddig, A   +9 more
core   +1 more source

Molecular evolution and functional characterization of Drosophila insulin-like peptides [PDF]

, 2010
Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and ...
Gronke, S, Clarke, DF, Linda Partridge, Partridge, Linda, Andrews, T., Partridge, L., Broughton, S, Broughton, Susan, David-Francis Clarke, T Daniel Andrews, Grönke, S., Andrews, T Daniel, Grönke, Sebastian, Broughton, S., Partridge, L, Sebastian Grönke, Andrews, TD, Susan Broughton, Andrews, T. Daniel, Clarke , D., Clarke, David-Francis   +20 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source