Results 21 to 30 of about 39,607,190 (300)
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
, 2005 Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz +12 more
core +1 more source
Insulin-Like Growth Factor 1 in Patients with Hypoglycaemia [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990 Plasma insulin-like growth factor 1 (IGF-1) concentrations were measured in a group of patients with hypoglycaemia due to endogenous hyperinsulinism, and compared with those in a group of patients matched for age and sex with hypoglycaemia and appropriately suppressed insulin levels. Insulin-like growth factor I concentrations were significantly higher
M, Labib, D, Teale, V, Marks
openaire +2 more sources
IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
Frontiers in Endocrinology, 2018 Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj +1 more source
Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Cell Death and Disease, 2022 Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala +6 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2018 Insulin-like growth factor binding protein-3 (IGFBP-3) is a vital protein exist in circulation which interacts with high affinity to insulin-like growth factor (IGFs) altering their activities.
Elham Jafari +6 more
doaj +1 more source
Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
doaj +1 more source
Meta‐analysis of peripheral insulin‐like growth factor 1 levels in schizophrenia
Brain and Behavior, 2023 Objective We aimed to investigate if there is a significant difference in peripheral insulin‐like growth factor 1 (IGF‐1) levels between schizophrenia patients and healthy controls and to determine whether a difference exists before and after initiation ...
Ana V. Pejcic +5 more
doaj +1 more source
Insulin-Like Growth Factor-1 as a Vascular Protective Factor [PDF]
Circulation, 2004 Recent advances in cardiology have focused on proliferation and regeneration as potential cardiovascular defense mechanisms. Within this framework, growth factors are acquiring increasing importance; insulin-like growth factor-1 (IGF-1) emerges among them for its versatile pleiotropic actions.
E. Conti +6 more
openaire +3 more sources
Revisiting the IGF-1R as a breast cancer target
npj Precision Oncology, 2017 The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj +1 more source
The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin [PDF]
Endocrinology and MetabolismThis review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important.
Eline C. Nijenhuis-Noort +3 more
doaj +1 more source