Results 251 to 260 of about 18,925,600 (331)

Perspectives on the Nutritional Paradox in Uremia: A "Sensitize-Then-Feed" Framework for Protein-Energy Wasting. [PDF]

Adv Nutr
Li M, Chen Z, Liu N, Lan N, Zeng F, Xue C, Yang B.   +6 more
europepmc   +1 more source

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

Advanced Science, EarlyView.
Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert, Lorena Garcia‐Castillo, Clarissa Murru, Adrien Casanova, Daniel Ferry, Pierre Perrin, Solene Coste, Anne Bigot, Anne‐Patricia Alloncle, Frederique Magdinier, Stefano Testa   +10 more
wiley   +1 more source

Size in small-for-gestational-age neonates correlates with insulin-like growth factor-binding protein proteolysis and insulin-like growth factor-I bioavailability. [PDF]

J Endocr Soc
Barrios V, Martín-Rivada Á, Martos-Moreno GÁ, Jiménez-Hernaiz M, Campillo-Calatayud A, Sánchez-Holgado M, Pellicer A, Chowen JA, Corredor-Andrés B, Soriano-Guillén L, Argente J.   +10 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Entresto attenuates dexamethasone-induced metabolic dysfunction-associated steatotic features in rats: role of potential SGK1/FOXO3a regulatory pathway and cardio-metabolic axis. [PDF]

Front Pharmacol
Alreshidi MK, Saad KM, Zaghloul MS, Nader MA.   +3 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Correlation of Salivary Insulin-Like Growth Factor-I With the Middle Phalanx of the Third Finger (MP3) Skeletal Maturation Stages Across Pubertal Transitions: A Cross-Sectional Study. [PDF]

Cureus
Awod N, Jatania A, Dagdiya MS, Akolkar A, Ahemad S, Pathak M, Niras A, Tayade S.   +7 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Beyond insulin-like growth factor-1 (IGF-1) normalization: portal insulin and hepatic growth hormone (GH) sensitivity across metabolic disease. [PDF]

Arch Endocrinol Metab
van AJ, Neggers SJ, Kopchick JJ, Boguszewski CL.   +3 more
europepmc   +1 more source

Perioperative Continuous Glucose Monitoring During Resection of a Giant Intrathoracic Solitary Fibrous Tumour Associated With Doege-Potter Syndrome. [PDF]

Interdiscip Cardiovasc Thorac Surg
Hayashi K, Kita Y, Nakamura R, Hanaoka J.   +3 more
europepmc   +1 more source