Results 271 to 280 of about 18,925,600 (331)
Some of the next articles are maybe not open access.
Secretion of insulin-like growth factor II into milk
Biochemical and Biophysical Research Communications, 1992125I-labeled insulin-like growth factor II (IGF-II) was infused directly into the pudic artery supplying one gland of lactating goats (n = 4). Maximum specific activity for [125I]IGF-II transferred into milk from the infused gland was reached 60 min after that in plasma and was 2.5 fold greater than in milk from the non-infused gland.
C G, Prosser, I R, Fleet
openaire +2 more sources
Insulin-Like Growth Factor II in Hepatocellular Carcinoma
Biomarkers in Medicine, 2007Hepatocellular carcinoma is one of the most common malignant human tumors. Hepatocarcinogenesis is a multistep process with a multifactorial etiology. Chronic hepatitis B and hepatitis C virus infection, alcohol drinking and cirrhosis of any etiology are the major risk factors for hepatocellular carcinoma.
Jeng-Eing, Jeng +4 more
openaire +2 more sources
The International Journal of Biochemistry & Cell Biology, 1999
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
C M, Nolan, M A, Lawlor
openaire +2 more sources
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
C M, Nolan, M A, Lawlor
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1986
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
P D, Lee +4 more
openaire +2 more sources
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
P D, Lee +4 more
openaire +2 more sources
Insulin-like growth factor II and nonsuppressible insulin-like activity levels in newborns
American Journal of Obstetrics and Gynecology, 1990We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. Our results obtained by use of one-way analysis of variance showed that the insulin-like growth factor II and ...
N A, Samaan, P N, Schultz, F K, Pham
openaire +2 more sources
Insulin-like growth factor II in the rat choroid plexus
Molecular Brain Research, 1988In situ hybridization histochemistry has been used to demonstrate the expression of the mRNA for insulin-like growth factor II (IGF-II) in the adult rat choroid plexus. IGF-II mRNA was found in the choroid plexus cells by using two different probes specific for different parts of IGF-II sequence.
Y, Ichimiya +3 more
openaire +2 more sources
Metabolic clearance of insulin-like growth factor-II in sheep
Journal of Endocrinology, 1989ABSTRACT The metabolic clearance of ovine insulin-like growth factor-II (IGF-II) was examined in sheep using 131I-labelled IGF-II. Following i.v. administration the tracer was distributed in a volume similar to that of the vascular space (58-5 ±3.3 ml/kg; mean ± s.e.m., n = 5) and demonstrated a triphasic pattern of clearance.
S C, Hodgkinson +4 more
openaire +2 more sources
Insulin-like growth factor II induces apoptosis in osteoblasts
Bone, 2004The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine orange-ethidium bromide staining.
Gloria A, Gronowicz +3 more
openaire +2 more sources
Insulin-Like Growth Factor-II Receptors
1990In the past few years there has been an explosive increase in interest in peptides of the insulin-like growth factor (IGF) family. This follows a period of over two decades, dating back to the discovery of “somatomedins,” as the IGFs were originally known, in the late 1950s.
Robert C. Baxter, Carolyn D. Scott
openaire +1 more source
Expression of insulin‐like growth factor II mRNA in hepatocellular carcinoma
Journal of Gastroenterology and Hepatology, 1998ABSTRACTInsulin‐like growth factor II (IGF‐II) is a mitogenic polypeptide closely related to insulin. Its gene has complex regulation of transcription, resulting in multiple mRNA initiated by different promoters. To study its role in hepatocarcinogenesis, we examined the expression of IGF‐II mRNA in hepatocellular carcinomas (HCC) and correlated it ...
Lee, JMF, Ng, M, Srivastava, G, Ng, IOL
openaire +3 more sources