Results 281 to 290 of about 830,008 (409)

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

open access: hybrid, 1989
Ikuo Nishimoto   +4 more
openalex   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang   +9 more
wiley   +1 more source

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

open access: hybrid, 1983
Catherine Oppenheimer   +4 more
openalex   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

open access: yesAdvanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye   +16 more
wiley   +1 more source

Fluorescence-Based Multiplex Western Blot to Simultaneously Detect the Insulin-Like Growth Factor-1 (IGF-1) Isoforms. [PDF]

open access: yesElectrophoresis
Bocconcelli M   +6 more
europepmc   +1 more source

Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide.

open access: hybrid, 1982
George L. King   +5 more
openalex   +1 more source

Growth hormone, insulin-like growth factor and the kidney

open access: yesKidney International, 1995
James C.M. Chan   +2 more
openaire   +3 more sources

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

open access: yesAdvanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang   +9 more
wiley   +1 more source

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