Results 281 to 290 of about 826,191 (386)

Insulin and Insulin-like Growth Factor I (IGF I) Stimulate Phosphorylation of a Mr 175,000 Cytoskeleton-associated Protein in Intact FRTL5 Cells

, 1989
Gianluigi Condorelli, Pietro Formisano, Giovanni Villone, Robert J. Smith, Francesco Béguinot   +4 more
openalex   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus.

Development
Kang SW, Helm BR, Wang Y, Xiao S, Zhang W, Vasudev A, Lau KS, Liu Q, Richie ER, Hale LP, Manley NR.   +10 more
europepmc   +1 more source

Purification and characterization of an insulin-like growth factor II variant from human plasma

, 1989
Brian Hampton, Wilson H. Burgess, D R Marshak, Kevin J. Cullen, James F. Perdue   +4 more
openalex   +1 more source

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cells

, 1989
Nobuyuki Takasu, Masaki Takasu, Ichiro Komiya, Yuya Nagasawa, Takayuki Asawa, Y. Shimizu, Takashi Yamada   +6 more
openalex   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Regulation of MAP Kinase signaling by the insulin-like growth factor pathway during <i>C. elegans</i> vulval development. [PDF]

MicroPubl Biol
Eroglu M, Derry WB.
europepmc   +1 more source