Results 51 to 60 of about 830,008 (409)

Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]

, 2018
Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said, Duggan, Christopher P., Fawzi, Wafaie W., Kisenge, Rodrick, Liu, Enju, Locks, Lindsey, Manji, Karim P., McDonald, Christine M., Sudfeld, Christopher, Syed, Sana   +9 more
core   +1 more source

Structural basis of the activation of type 1 insulin-like growth factor receptor

Nature Communications, 2019
Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we report the cryo-EM structure of full-length IGF1R–IGF1 complex in the
Jie Li, E. Choi, Hongtao Yu, X. Bai
semanticscholar   +1 more source

Kinetics of urinary cell cycle arrest markers for acute kidney injury following exposure to potential renal insults [PDF]

, 2018
Objectives: Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology.
Aliaga, Bellomo, Bihorac, Bonventre, Charlton, Emlet, Goldstein, Gunnerson, Honore, Hoste, Hoste, Jia, Joannidis, Kane-Gill, Kashani, Kaufman, Kerr, Lewington, McDonald, Meersch, Mehta, Mehta, Murrary, Peng, Perazella, Uchino, Waring, Wu   +27 more
core   +1 more source

The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System

Biochemistry Insights, 2019
The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in nervous tissue from early embryonic life. They also cross the blood brain barriers by active transport, and their regulation as endocrine factors therefore ...
M. Lewitt, Gary W Boyd
semanticscholar   +1 more source

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

BMC Endocrine Disorders, 2018
Background Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP).
Hua-Pin Chang, Shun-Fa Yang, Shu-Li Wang, Pen-Hua Su   +3 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B [PDF]

, 2013
Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity.
Barcos, Lucía Soledad, Coluccio Leskow, Federico, Giordano, Luciana, Giudice, Jimena, Guaimas, Francisco Fernando, Jares, Elizabeth Andrea, Penas Steinhardt, Alberto   +6 more
core   +3 more sources

The insulin-like growth factor-binding protein (IGFBP) superfamily.

Endocrine reviews, 1999
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open.
V. Hwa, Y. Oh, Ron G. Rosenfeld
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source