Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Tumor Biology, 2017 MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer.
Hui Pang, Xiuying Yue
doaj +1 more source
Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies [PDF]
, 1991 I Dørup +3 more
openalex +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Epithelial localization of insulin-like growth factor binding protein 1 in the uterus of the rat during pregnancy, deciduoma-bearing pseudopregnancy and hormone treatment [PDF]
, 1994 Sherif Sadek +2 more
openalex +1 more source
Tunable Thermoshrinkable Hydrogels for 4D Fabrication of Cell‐Seeded Channels
Advanced Functional Materials, EarlyView.A thermoresponsive polymer with methacrylate groups for photo‐cross‐linking, based on polyethylene glycol, N‐isopropylacrylamide, and 2‐hydroxyethyl acrylate is synthetized to yield hydrogels that shrink upon temperature increase. The new polymer enables the fabrication of cell‐laden perfusable channels with diameters below 200 µm by combining ...
Greta Di Marco +12 more
wiley +1 more source
Effects of Hormones on Tumor Growth and Immunoreactive Insulin–like Growth Factor–1 of Estrogen Receptor–positive Human Breast Cancer (MCF‐7) Transplanted in Nude Mice [PDF]
, 1991 Masakuni Noguchi +3 more
openalex +1 more source
Advanced Functional Materials, EarlyView.The study presents an injectable hydrogel with tunable microporosity to improve mesenchymal stem cell delivery for volumetric muscle loss treatment. Mesenchymal stem cells encapsulated in porous hydrogels significantly promote the spreading, proliferation, and cytokine secretion of mesenchymal stem cells.
Hana Yasue +3 more
wiley +1 more source
Serum Concentrations of Insulin-Like Growth Factor 1 in Colonic Neoplasia [PDF]
, 1994 Allan R. Glass +3 more
openalex +1 more source
Challenges of insulin-like growth factor-1 testing
Critical Reviews in Clinical Laboratory SciencesInsulin-like growth factor 1 (IGF-1), primarily synthesized in the liver, was initially discovered due to its capacity to replicate the metabolic effects of insulin. Subsequently, it emerged as a key regulator of the actions of growth hormone (GH), managing critical processes like cell proliferation, differentiation, and apoptosis.
Rongrong Huang +3 more
openaire +2 more sources