Results 261 to 270 of about 635,173 (353)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

RETRACTED ARTICLE: Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway

, 2019
Yuzheng Zhou, Qianqian Zhang, Yangyang Kong, Xiaohong Guo, Haiyan Zhang, Huiqin Fan, Lixin Liu   +6 more
openalex   +1 more source

Insulin-Like Growth Factor-Binding Protein 1 [PDF]

, 2020
openaire   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Neurodegenerative processes of aging: A perspective of restoration through insulin-like growth factor-1. [PDF]

Neural Regen Res
Crespo R, Hereñú C.
europepmc   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

The correlation between insulin-like growth factor 1 and left ventricular mass index in obese children. [PDF]

BMC Endocr Disord
Niu W, Li C, Wang Z, Liang S.
europepmc   +1 more source

DIFFERENTIAL EFFECTS OF GROWTH HORMONE FAMILY PEPTIDES ON THE EXPRESSION OF INSULIN-LIKE GROWTH FACTOR 1 AND 2 mRNAs

, 2011
Sheridan Mark
openalex   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source