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Insulin-Like Growth Factor Binding Protein-3

1994
In plasma and other biological fluids insulinlike growth factors are bound to a family of structurally homologous binding proteins (IGFBPs).
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Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk

American Journal of Epidemiology, 2008
Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and ...
Victoria M, Chia   +6 more
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Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling

European Journal of Pharmacology
Fluoroquinolones (FQs), commonly known for their antibiotic properties, exhibit additional pharmacological potential with anti-proliferative effects on various malignant cell types and immunomodulatory responses. Despite these observed effects, the precise mechanisms of action remain elusive.
Chih-Ling Chung, Chun-Lin Chen
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Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome

Fertility and Sterility, 1998
To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression.Prospective trial.Department of Obstetrics and Gynecology, University of California, Los Angeles.After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study ...
A J, Rapkin   +3 more
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Insulin-like growth factor-I/insulin-like growth factor binding protein-3 alters lymphocyte responsiveness following severe burn

Journal of Surgical Research, 2004
Following severe burn, patients are immunocompromised, making them at increased risk for infection. Exogenous growth hormone has been shown to partially restore immune function. Herein, we investigated Th1/Th2 cytokine profiles and cellular proliferation in isolated mononuclear cells after treatment with exogenous insulin-like growth factor-I (IGF-I ...
Steven E, Wolf   +5 more
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Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Obese Children

Journal of Pediatric Endocrinology and Metabolism, 1997
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) metabolism may be disturbed in obese children. We investigated serum GH, IGF-I, IGF-binding protein-3 (IGFBP-3) levels in 42 obese and 40 non-obese healthy children aged 6-14 years. GH stimulation tests with L-dopa and insulin were performed.
Bideci, AYSUN   +3 more
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Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 in premature rupture of membranes

Acta Obstetricia et Gynecologica Scandinavica, 2002
Background.  The aim of the study was to evaluate whether the circulating levels of insulin‐like growth factor‐I (IGF‐I) and its major circulating binding protein, IGFBP‐3, are affected in premature rupture of membranes (PROM) and preterm delivery.Methods.
Mikko, Loukovaara   +5 more
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Somatomedin-1 binding protein-3

BioDrugs, 2003
Somatomedin-1 binding protein-3 [insulin-like growth factor-1 binding protein-3, SomatoKine] is a recombinant complex of insulin-like growth factor-1 (rhIGF-1) and binding protein-3 (IGFBP-3), which is the major circulating somatomedin (insulin-like growth factor) binding protein; binding protein-3 regulates the delivery of somatomedin-1 to target ...
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Insulin-like growth factor binding protein-3 in normal pubertal girls

Acta Endocrinologica, 1992
IGFBP-3 concentrations rise in the second decade of life. To test the hypothesis that the stage of pubertal development, independent of chronological age, was associated with these increases we measured serum IGFBP-3 concentrations by radioimmunoassay in 324 sixth and seventh grade girls (12.3±0.7 years) at the beginning of a multisite school-based ...
D M, Wilson   +6 more
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Insulin-like growth factor–binding protein-3 and breast cancer survival

International Journal of Cancer, 1998
Insulin-like growth factors (IGFs) are potent mitogens involved in the regulation of cell proliferation and apoptosis. The action of IGFs is mediated through a specific cell membrane receptor (IGF-IR), and the interactions between IGFs and this receptor are regulated by IGF-binding proteins (IGFBPs).
H, Yu   +5 more
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