Results 231 to 240 of about 356,438 (307)

Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.

Journal of the National Cancer Institute, 2009
M. Gunter, D. Hoover, Herbert Yu, S. Wassertheil-Smoller, T. Rohan, J. Manson, Jixin Li, G. Ho, X. Xue, G. Anderson, R. Kaplan, Tiffany G. Harris, B. Howard, J. Wylie-Rosett, R. Burk, H. Strickler   +15 more
semanticscholar   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Co-Administration of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-1 Stimulates Wound Healing in Animal Models

, 1995
Ryoji Tsuboi, Chog-Ming Shi, Chiyo Sato, George N. Cox, Hideoki Ogawa   +4 more
openalex   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

The Associations Between Serum Insulin-like Growth Factor-I, Brain White Matter Volumes, and Cognition in Mild Cognitive Impairment and Alzheimer's Disease. [PDF]

J Alzheimers Dis
Horvath A, Quinlan P, Eckerström C, Åberg ND, Wallin A, Svensson J.   +5 more
europepmc   +1 more source

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

Molecular and Cellular Biology, 1994
C. Sell, G. Duménil, C. Deveaud, M. Miura, D. Coppola, T. Deangelis, R. Rubin, A. Efstratiadis, R. Baserga   +8 more
semanticscholar   +1 more source

Angiotensin II and its association with insulin-like growth factor-I, insulin and follicular cells on bovine oocyte maturation and consequent embryo development

, 2005
Jerônimo Rubert Stefanello
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

U-Shaped relationship of insulin-like growth factor I and incidence of nonalcoholic fatty liver in patients with pituitary neuroendocrine tumors: a cohort study. [PDF]

Front Endocrinol (Lausanne)
Hu Y, Yuan C, Abdulnaimu M, Memetmin J, Jie Z, Tuhuti A, Abudueini H, Guo Y.   +7 more
europepmc   +1 more source

Elevated levels of circulating insulin-like growth factor-I, IGF-binding globulin-3 and testosterone predict hormone-dependent breast cancer in postmenopausal women: A case-control study

, 2006
Zsuzsanna Kahán, János Gardi, Tibor Nyári, Imre Földesi, Rozália Hajnal-Papp, Katalin Ormándi, György Lázár, László Thurzó, Andrew V. Schally   +8 more
openalex   +2 more sources