Results 351 to 360 of about 590,806 (400)

Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth.

Pediatrics, 2003
OBJECTIVE Insulin-like growth factor I (IGF-I) is necessary for normal development of retinal blood vessels in mice and humans. Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that ...
A. Hellström, E. Engström, A. Hård, K. Albertsson-Wikland, B. Carlsson, A. Niklasson, Chatarina Löfqvist, E. Svensson, S. Holm, U. Ewald, G. Holmström, Lois E. H. Smith   +11 more
semanticscholar   +1 more source

Insulin-like growth factor-I and cancer risk

Growth Hormone & IGF Research, 2004
Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on ...
Douglas Yee, Yasir H. Ibrahim
openaire   +3 more sources

Insulin-like growth factor-I and diabetes. A review

Growth Hormone & IGF Research, 1998
Although diabetes is a heterogeneous condition, IGF-I has been shown to improve glycaemic control and reduce insulin requirements in both IDDM and NIDDM. In IDDM, the therapeutic rationale for IGF-I is as a replacement therapy "topping up" low circulating IGF-I levels.
Helen Simpson, Anne Umpleby, David Russell-Jones   +2 more
openaire   +3 more sources

Insulin-like Growth Factor I Receptors [PDF]

, 1990
The somatomedins, insulin-like growth factor-I or somatomedin-C, and insulinlike growth factor-II or multiplication-stimulating activity, are polypeptides that play an important, but not completely defined role in regulating growth and differentiation (FROESCH et al. 1985). IGF-I is synthesized and secreted by a variety of tissues in response to growth
openaire   +1 more source

The insulin-like growth factor-I receptor as an oncogene

Archives of Physiology and Biochemistry, 2009
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic, cell-survival, and transforming activities. IGF-IR expression is a fundamental prerequisite for the acquisition of a malignant phenotype, as suggested by ...
Ilan Bruchim, Haim Werner
openaire   +3 more sources

Nutritional regulation of insulin-like growth factor-I

Metabolism, 1995
Several lines of evidence indicate that in the human, insulin-like growth factor-I (IGF-I) is nutritionally regulated. Both energy and protein availability are required for maintenance of IGF-I. Measurements of serum IGF-I constitute a sensitive means for monitoring the response of acutely ill patients to nutritional intervention.
Marc Maes, Marc Maes, Dominique Maiter, Dominique Maiter, Jean-Marie Ketelslegers, Jean-Paul Thissen, Jean-Paul Thissen, Louis E. Underwood, Louis E. Underwood   +8 more
openaire   +3 more sources

Insulin‐like growth factor I in growing thoroughbreds

Journal of Animal Physiology and Animal Nutrition, 2007
SummaryThe objective of this longitudinal study was to characterize growth and plasma insulin‐like growth factor I (IGF‐I) concentrations in pasture‐raised thoroughbreds fed two sources of dietary energy. Mares and foals were randomly assigned to either a sugar and starch (SS) or fat and fibre (FF)‐rich feed, and plasma IGF‐I and growth were measured ...
R. M. Akers, D. S. Kronfeld, Pat Harris, W. B. Staniar   +3 more
openaire   +3 more sources

Insulin-Like Growth Factor-I in Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition, 1994
To contribute to the description of the physiopathological mechanisms of celiac disease, changes in insulin-like growth factor I (IGF-I) were followed-up in 21 children suspected of suffering from celiac disease. Thirteen children were suffering from celiac disease according to the original criteria of the European Society of Paediatric ...
Peter A. Krasilnikoff, Niels E. Skakkebæk, Birgitte Weile, Aleksander Giwercman   +3 more
openaire   +3 more sources

Acromegaly and Serum Insulin-Like Growth Factor I

Hormone Research in Paediatrics, 2004
Random levels of growth hormone (GH) are usually not helpful in diagnosing either GH deficiency or GH hypersecretion because GH is secreted in a pulsatile fashion. Insulin-like growth factor I (IGF-I), however, is a good indicator of GH secretion and action, particularly at the level of the liver.
openaire   +3 more sources

Drug delivery of Insulin-like growth factor I

European Journal of Pharmaceutics and Biopharmaceutics, 2015
This review starts off outlining the control of Insulin-like growth factor I (IGF-I) kinetics in Nature and by virtue of a complex system of 6 binding proteins controlling half-life and tissue distribution of this strong anabolic peptide. In addition, alternative splicing is known to result in IGF-I variants with modulated properties in vivo and this ...
Isabel Schultz, Joel Wurzel, Lorenz Meinel   +2 more
openaire   +3 more sources