Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease [PDF]
Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro.
Ellen M. Zimmermann+4 more
openaire +3 more sources
Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells.
Seyed Ahmad Hosseini+2 more
doaj +1 more source
Obesity and breast cancer in premenopausal women: Current evidence and future perspectives [PDF]
There is raising evidence reporting an increased incidence of breast cancer over the past decades. Every year approximately 1.4 million new cases of breast cancer are diagnosed worldwide, with a mortality rate of approximately 450,000/year.
Barrea, Luigi+4 more
core +1 more source
Cardiovascular Disease and Insulin-Like Growth Factor I [PDF]
The research field of cardiovascular disease in regard to growth hormone (GH) and its mitogenic mediator insulin-like growth factor I (IGF-I) has a long and distinguished history and is still intensively studied. Medline searches reveal that more than 1000 articles have appeared, demonstrating the importance of IGF-I in development of (and for lesions ...
Frystyk, J.+4 more
openaire +2 more sources
Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]
Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P.+6 more
core +1 more source
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos [PDF]
We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages, mRNA and protein for IGF-II were expressed in ...
Behrendtsen, Ole+5 more
core +2 more sources
The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan+7 more
doaj +1 more source
Insulin-like growth factor I (IGF-I) and liver cirrhosis [PDF]
Insulin-like growth factor I (IGF-I) is a polypeptide hormone secreted by multiple tissues in response to growth hormone (GH). It is partly responsible for GH activity, and also has glucose-lowering and anabolizing effects.
Conchillo, M. (M.)+2 more
core
Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. [PDF]
We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity.
C J Auernhammer+4 more
core +1 more source
We investigated concentrations and roles of insulin-like growth factor 1 (IGF-1) and its binding protein (IGF1BP-3), growth hormone (GH), insulin, and markers of insulin resistance and inflammation in acute myocardial infarction (AMI). We aimed to assess
Larisa Dizdarević-Hudić+4 more
doaj +1 more source