Results 41 to 50 of about 590,806 (400)

Characteristics and treatment outcomes of micromegaly – acromegaly with apparently normal basal GH: A retrospective study and literature review

Endocrine Regulations, 2022
Objective. Micromegaly describes a subgroup of patients with clinically evident acromegaly and elevated insulin-like growth factor I (IGF-I) with apparently normal basal growth hormone (bGH) and often a glucose-suppressed growth hormone (GH) of
Inacio Isabel, Fonseca Liliana, Amado Ana, Benido Vania, Ribeiro Isabel, Dores Jorge, Amaral Claudia, Cardoso Maria Helena   +7 more
doaj   +1 more source

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

Frontiers in Endocrinology, 2023
IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation.
Stefania Stella, Stefania Stella, Michele Massimino, Michele Massimino, Livia Manzella, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Silvia Rita Vitale, Federica Martorana, Federica Martorana, Paolo Vigneri, Paolo Vigneri, Paolo Vigneri   +13 more
doaj   +1 more source

Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro.
Ellen M. Zimmermann, Lina Li, Yanan Hou, Nirupama K. Mohapatra, Jolanta B. Pucilowska   +4 more
openaire   +3 more sources

Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

New England Journal of Medicine, 1996
Insulin-like growth factor I (IGF-I) mediates the majority of the growth-promoting effects of growth hormone (GH) after birth.1 In the prenatal period, GH does not appear to have a major influence on fetal growth, whereas IGF-I does.
K. Woods, C. Camacho‐Hübner, M. Savage, A. Clark   +3 more
semanticscholar   +1 more source

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits [PDF]

, 2016
The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including ...
Aschard, H. (Hugues), Bandinelli, S. (Stefania), Beekman, M. (Marian), Berndt, S.I. (Sonja), Bidlingmaier, M. (Martin), Broer, L. (Linda), Cappola, A.R. (Anne), Ceda, G.P. (Gian Paolo), Chanock, S.J. (Stephen), Chen, M.-H. (Ming-Huei), Chen, T.C. (Tai C.), Chen, Y.D. (Y.), Chung, J. (Jonathan), Del Greco Miglianico, F. (Fabiola), Duijn, C.M. (Cornelia) van, Eriksson, J. (Joel), Ferrucci, L. (Luigi), Friedrich, N. (Nele), Gnewuch, C. (Carsten), Goodarzi, M. (Mark), Grarup, N. (Niels), Guo, T. (Tingwei), Hammer, E. (Elke), Hayes, R.B. (Richard), Heemst, D. (Diana) van, Hicks, A.A. (Andrew), Hofman, A. (Albert), Houwing-Duistermaat, J.J. (Jeanine), Hu, F. (Frank), Hunter, D. (David), Husemoen, L.L.N. (Lise Lotte), Isaacs, A.J. (Aaron), Jacobs, K.B. (Kevin), Janssen, J.A.M.J.L. (Joop), Jansson, J.-O. (John-Olov), Jehmlich, N. (Nico), Johnson, S. (Simon), Juul, A. (Anders), Kaplan, R.C. (Robert), Karlsson, M. (Magnus), Kilpeläinen, T.O. (Tuomas), Kovacs, P. (Peter), Kraft, P. (Peter), Li, C. (Chao), Linneberg, A. (Allan), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lorentzon, M. (Mattias), Lu, Y. (Yingchang), Maggio, M. (Marcello), Meigs, J.B. (James), Mellström, D. (Dan), Mägi, R. (Reedik), Nauck, M. (Matthias), Nethander, M. (Maria), Newman, A.B. (Anne B.), Ohlsson, C. (Claes), Pollak, M.N. (Michael), Pramstaller, P.P. (Peter Paul), Prokopenko, I. (Inga), Psaty, B.M. (Bruce), Qi, Q., Reincke, M. (Martin), Rimm, E.B. (Eric B.), Rotter, J.I. (Jerome I.), Saint Pierre, A. (Aude), Schurmann, C. (Claudia), Seshadri, S. (Sudha), Sjögren, K. (Klara), Slagboom, P.E. (Eline), Strickler, H.D. (Howard D.), Stumvoll, M. (Michael), Suh, Y. (Yousin), Sun, Q. (Qi), Svensson, J. (Johan), Tanaka, T. (Toshiko), Tare, A. (Archana), Teumer, A. (Alexander), Tönjes, A. (Anke), Uh, H.-W. (Hae-Won), Vandenput, L. (Liesbeth), Vasan, R.S. (Ramachandran Srini), Völker, U. (Uwe), Wallaschofski, H. (Henri), Willems, S.M. (Sara), Zhang, C. (Cuilin)   +85 more
core   +1 more source

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

Proceedings of the National Academy of Sciences of the United States of America, 1993
High levels of extracellular K+ ensure proper development and prolong survival of cerebellar granule neurons in culture. We find that when switched from a culture medium containing high K+ (25 mM) to one containing a low but more physiological K ...
S. D’Mello, C. Galli, T. Ciotti, P. Calissano   +3 more
semanticscholar   +1 more source

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Journal of Neuroscience, 2000
Physical exercise increases brain activity through mechanisms not yet known. We now report that in rats, running induces uptake of blood insulin-like growth factor I (IGF-I) by specific groups of neurons throughout the brain.
E. Carro, Á. Núñez, S. Busiguina, I. Torres-Alemán   +3 more
semanticscholar   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea, Fruth, Maximilian, Kraus, Steffen, Nägler, Dorit K.   +3 more
core   +1 more source

The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)

Animals, 2020
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan, Chaobin Qin, Guokun Yang, Dapeng Deng, Liping Yang, Junchang Feng, Jiali Mi, Guoxing Nie   +7 more
doaj   +1 more source

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

Journal of the National Cancer Institute, 2001
BACKGROUND Trastuzumab (Herceptin), an anti-HER2/neu receptor monoclonal antibody that inhibits growth of ErbB2-overexpressing breast cancer, is used to treat such cancers. Development of resistance to trastuzumab, however, is common.
Yuhong Lu, X. Zi, Yunhua Zhao, D. Mascarenhas, M. Pollak   +4 more
semanticscholar   +1 more source