Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula [PDF]
, 1991 Completely diverting portacaval shunt (Eck's fistula) in dogs causes hepatocyte atrophy, disruption of hepatocyte organelles, fatty infiltration and lowgrade hyperplasia. The effect of hepatic growth regulatory substances on these changes was assessed by
Azzarone, A +9 more
core +1 more source
Late recurrence of a malignant hypoglycemia-inducing pelvic solitary fibrous tumor secreting high-molecular-weight insulin-like growth factor-II: A case report with protein analysis. [PDF]
Oncol Lett, 2016 The present study reports a case of recurrent malignant pelvic solitary fibrous tumor (SFT) that induced non-islet cell tumor hypoglycemia via high-molecular-weight insulin-like growth factor-II in a 72-year-old male patient. The tumor recurred ~12 years
Ishihara H +8 more
europepmc +3 more sources
Molecular Endocrinology, 1989 Insulin-like growth factor-II (IGF-II) is a potent mitogen for several types of cultured cells and tissues. We have studied the interaction of IGF-II with a panel of cultured human breast cancer cell lines, examining the possibility that these cells ...
K. Osborne +7 more
semanticscholar +1 more source
Understanding IGF-II Action through Insights into Receptor Binding and Activation
Cells, 2020 The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and ...
Andrew J. Blyth +2 more
doaj +1 more source
Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.
PLoS ONE, 2019 Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett +4 more
doaj +1 more source
Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [PDF]
, 2015 The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment.
Daniela A. Ferraro +6 more
core +1 more source
The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]
, 2016 Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Aplin, JD +5 more
core +1 more source
Prostat adenokarsinomlarında IMP-3 ekspresyonunun araştırılması [PDF]
, 2012 Objective: Prostate cancer is the second most common cause of male cancer deaths after lung cancer in developed countries. The prognostic factors currently identified for prostate carcinoma include preoperative serum PSA, TNM staging system, histological
Tosun Yıldırım, Hülya +1 more
core +1 more source
Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
Journal of Translational Medicine, 2011 Background Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rats reducing oxidative damage in ...
Castilla-Cortazar Inma +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1999 Genomic imprinting plays a fundamental role in cancer and some hereditary diseases, including Beckwith-Wiedemann syndrome (BWS), a disorder of prenatal overgrowth and predisposition to embryonal malignancies such as Wilms tumor.
Maxwell P. Lee +6 more
semanticscholar +1 more source