Results 61 to 70 of about 463,657 (378)
Insulin-like growth factors I and II in evaluation of growth retardation
The Journal of Pediatrics, 1986 Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level less than 7 ng/ml), 44 normal short children, and 197 children with normal height were assayed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II.
Darrell M. Wilson +3 more
openaire +3 more sources
Journal of Biological Chemistry, 1999 Insulin-like growth factors (IGFs) are potent inducers of skeletal muscle differentiation and phosphatidylinositol (PI) 3-kinase activity is essential for this process. Here we show that IGF-II induces nuclear factor-κB (NF-κB) and nitric-oxide synthase (
P. Kaliman +4 more
semanticscholar +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Exploring metabolic dysfunction in chronic kidney disease [PDF]
, 2012 Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
core +2 more sources
Annals of Internal Medicine: Clinical Cases, 2022 A 60-year-old man with a history of metastatic intracranial hemangiopericytoma and type 2 diabetes mellitus presented with acute episodes of confusion and dizziness.
Natnicha Leelaviwat +4 more
doaj +1 more source
Journal of Biological Chemistry, 2005 IMP-3, a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein (IMP) family, is expressed mainly during embryonic development and in some tumors. Thus, IMP-3 is considered to be an oncofetal protein. The functional significance of IMP-
B. Liao, Yan Hu, D. Herrick, G. Brewer
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The Intrathymic Expression of Insulin-Related Genes: Implications for Pathophysiology and Prevention of Type 1 Diabetes [PDF]
, 1998 peer reviewedRecent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment.
Geenen, Vincent, Lefebvre, Pierre J.
core +1 more source
A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease. [PDF]
PLoS ONE, 2015 Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to ...
Eirini Kalliolia +10 more
doaj +1 more source