Results 81 to 90 of about 463,657 (378)

Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility

Genetics and Molecular Biology, 2004
Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with
Yao-Yuan Hsieh, Chi-Chen Chang, Fuu-Jen Tsai, Ching-Tien Peng, Lian-Shun Yeh, Cheng-Chieh Lin   +5 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

β‐Galactosidase decreases the binding affinity of the insulin‐like‐growth‐factor‐II/mannose‐6‐phosphate receptor for insulin‐like‐growth‐factor II [PDF]

European Journal of Biochemistry, 1990
The insulin‐like growth‐factor‐II/mannose‐6‐phosphate (IGF‐II/Man6P) receptor binds two classes of ligands, insulin‐like growth factors and lysosomal enzymes. We have examined the ability of the lysosomal enzyme, β‐galactosidase, to modulate the binding of 125I‐IGF‐II to the receptor.
Wieland Kiess, Mark M. Sklar, Cheryl L. Thomas, S. Peter Nissley   +3 more
openaire   +3 more sources

Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis.

Cancer Research, 2007
MicroRNAs (miRNA) are endogenous noncoding small RNAs that regulate the activity of mRNAs. Many miRNA genes, including let-7a-3, are located in CpG islands, suggesting possible epigenetic regulation of their expression. Promoter CpG island methylation of
Lingeng Lu, D. Katsaros, I. A. R. de la Longrais, Olga Sochirca, Herbert Yu   +4 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression [PDF]

, 2019
OBJECTIVE: The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes.
Chan, Albert, Eckert, George J., Kirmani, Kashif, Shi, Shuiliang, Trippel, Stephen B., Wang, Congrong   +5 more
core   +1 more source

Retroperitoneal Doege–Potter syndrome with intraoperative blood glucose monitoring

IJU Case Reports
Background Doege–Potter syndrome, characterized by solitary fibrous tumors and non‐islet cell tumor hypoglycemia, is rare. Here, we report a case of Doege–Potter syndrome in which retroperitoneal tumor resection was performed with continuous ...
Hirotaka Nagasaka, Takahisa Suzuki, Takuya Kondo, Mitsuyuki Koizumi, Hideyuki Terao, Yuko Murohashi, Yoichiro Okubo, Tomoyuki Yokose, Takeshi Kishida   +8 more
doaj   +1 more source

Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin.
Anastasios Papaioannou, Serdar Kuyucak, Zdenka Kuncic   +2 more
doaj   +1 more source

Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor [PDF]

Diabetologia, 1992
Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric acid and [14C]lactate formation from ...
T. Braulke, Heinz Hartmann, A. Meyer-Alber   +2 more
openaire   +3 more sources

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

Journal of Neuroscience, 1986
Insulin and the insulin-like growth factors (IGFs) may directly affect the development of the nervous system. NGF, IGF-II, and insulin's effects on neurite formation and neuronal survival were studied in peripheral ganglion cell cultures from chick ...
E. Recio-Pinto, MM Rechler, D. Ishii
semanticscholar   +1 more source