Results 241 to 250 of about 14,458,916 (288)
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Insulin-Like Growth Factor Receptors
Growth Factors, 1991AbstractCompetitive binding experiments from a number of laboratories showed that IGF receptors are distinct from insulin receptors, and that there are two types of IGF receptors based on their relative affinities for IGF-I and IGF-II and whether or not they bind insulin (reviewed in Rechler and Nissley, 1985).
P, Nissley, W, Lopaczynski
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Insulin-like growth factors: Ligands, binding proteins, and receptors
Molecular Metabolism, 2021 The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.Insulin and insulin receptors are the focus of other chapters in this series and will therefore not be discussed
Derek LeRoith +2 more
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The insulin-like growth factor-I receptor as an oncogene
Archives of Physiology and Biochemistry, 2009The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic, cell-survival, and transforming activities. IGF-IR expression is a fundamental prerequisite for the acquisition of a malignant phenotype, as suggested by ...
Haim Werner, Ilan Bruchim
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Insulin-like growth factor receptors
Journal of Cell Science, 1985ABSTRACT There are two types of insulin-like growth factor (IGF) receptors. The type I receptor generally binds IGF-I more tightly than IGF-II and also interacts weakly with insulin. The type II receptor prefers IGF-II over IGF-I and does not recognize insulin.
S P, Nissley +4 more
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The Nature and Regulation of the Receptors for Insulin-Like Growth Factors
Annual Review of Physiology, 1985Two subtypes of IGF receptors have been identified. Type I IGF receptors have a Mr greater than 300,000 and are composed of disulfide-linked 130,000-dalton (alpha) and approximately 90,000-dalton (beta) subunits. The alpha subunit binds hormone; the beta subunit appears to have intrinsic tyrosine kinase activity and to be autophosphorylated.
M M, Rechler, S P, Nissley
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RECEPTORS FOR THE INSULIN-LIKE GROWTH FACTORS ON HUMAN EKYTHKUUYTES
The Journal of Clinical Endocrinology & Metabolism, 1983We have examined the presence and properties of specific receptors for the insulin-like growth factors (IGFs) on human erythrocytes (RBC). HPLC purified IGF-I and II peptides were used as ligands. RBCs were separated in density fractions representing cell groups of different ages. Binding to all cell fractions was found for both IGF tracers.
C, Polychronakos +2 more
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Insulin-like growth factor receptors
1992Abstract Insulin and the insulin-like growth factors (IGFs) have an overlapping range of biological activities. Early competitive-binding studies demon strated that although IGF-I and -II bind weakly to insulin receptors, they have their own distinct, high-affinity receptors, and that there may be some heterogeneity amongst these ...
Cary Moxham, Steven Jacobs
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH
Endocrinology and Metabolism Clinics of North America, 1996The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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Insulin‐Like Growth Factor II Effects Mediated through Insulin‐Like Growth Factor II Receptors
Acta Paediatrica, 1990ABSTRACT. Insulin‐like growth factor II (IGF‐II) resembles the homologous peptide insulin‐like growth factor I (IGF‐I) in that it stimulates cellular growth in vitro. This effect is generally believed to be mediated through IGF type 1 receptors; the role of the IGF type 2 receptor remains, as yet, unknown.
M, Tally, K, Hall
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