Results 261 to 270 of about 14,458,916 (288)

Insulin-Like Growth Factor-I is Internalized after Binding to the Type I Insulin-Like Growth Factor Receptor

Hormone and Metabolic Research, 1989
Receptor-mediated endocytosis may represent an important mechanism whereby peptide hormones exert their biological effects. The ability of recombinant insulin-like growth factor (IGF)-I to be internalized by cultured cells was evaluated in BRL-3A2 cells, a rat liver-derived cell line which lacks insulin receptors.
E S, Geary, R G, Rosenfeld, A R, Hoffman
openaire   +2 more sources

Targeting insulin-like growth factor 1 receptor in sarcomas

Current Opinion in Oncology, 2008
The present review examines the rationale for targeting insulin-like growth factor-I receptor in sarcoma therapy and highlights some key issues that need to be addressed as clinical trials targeting insulin-like growth factor-I receptor proceed.Preclinical evidence supports proof of principle for targeting insulin-like growth factor-I receptor ...
Katia, Scotlandi, Piero, Picci
openaire   +2 more sources

Insulin and insulin-like growth factor receptors in the nervous system

Molecular Neurobiology, 1989
Insulin and the insulin-like growth factors (I and II) are homologous peptides essential to normal metabolism as well as growth. These peptide hormones are present in the brain, and, based on biosynthetic labeling studies as well as evidence for local gene expression, they are synthesized by nervous tissue as well as being taken up by the brain from ...
M, Adamo, M K, Raizada, D, LeRoith
openaire   +2 more sources

Insulin-like Growth Factor I Receptors

1990
The somatomedins, insulin-like growth factor-I or somatomedin-C, and insulinlike growth factor-II or multiplication-stimulating activity, are polypeptides that play an important, but not completely defined role in regulating growth and differentiation (FROESCH et al. 1985). IGF-I is synthesized and secreted by a variety of tissues in response to growth
openaire   +1 more source

Insulin-Like Growth Factor Receptors in Rat Placental Membranes*

Endocrinology, 1984
The nature and relative quantity of insulin-like growth factor (IGF) receptors in rat placental microsomal membranes was investigated by competitive binding studies and covalent cross-linking followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
S J, Pilistine, A C, Moses, H N, Munro
openaire   +2 more sources

Enhancement of insulin-like growth factor 2 receptors in glioblastoma

Cancer Letters, 1986
The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which have been identified in the human central nervous system where their specific receptors are distributed. The present study identified somatomedin receptors in glioblastoma and compared them with those found in normal brain.
V R, Sara, P, Prisell, B, Sjögren, L, Persson, J, Boethius, G, Enberg   +5 more
openaire   +2 more sources

Receptors for insulin‐like growth factors

Journal of Internal Medicine, 1989
U, Smith, J, Eriksson, P, Lönnroth
openaire   +2 more sources

Systemic therapy for hormone receptor-positive/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Özge Gümüşay, Laura A Huppert   +2 more
exaly  

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

Neuroscience, 1992
Haim Werner, Charles T. Roberts, C Bondy
exaly  

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Journal of Cell Biology, 2001
Naoyuki Inagaki, Kozo Kaibuchi, Akihiro Iwamatsu   +2 more
exaly