Results 251 to 260 of about 14,458,916 (288)

Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor

The Journal of Pathology, 1999
Haemangiopericytoma is a rare soft tissue tumour originating from the contractile pericapillary cells. Relatively little is known about its molecular pathogenesis. To address this issue, the insulin-like growth factor family (IGFs) was analysed in 19 tumours collected from a human tumour bank network.
Pavelić, Krešimir, Pavelić, Zlatko Paul, Čabrijan, Tomislav, Karner, Ivan, Samaržija, Miroslav, Stambrook, Peter J.   +5 more
openaire   +3 more sources

Insulin-Like Growth Factors and Their Receptors in Muscle Development

1991
Several proteins involved in IGF action are expressed in C2 cells and their abundance was found to vary as a function of development. IGF-I and II mRNA levels rose 10 and 25-fold, respectively, during differentiation, and were accompanied by an increase in growth factor secretion.
G, Szebenyi, P, Rotwein
openaire   +2 more sources

The Insulin-Like Growth Factor-I Receptor

Hormone Research, 2008
The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our recently proposed novel binding mechanism whereby the bivalent ligand bridges the two receptor α-subunits alternatively at opposite sites in a symmetrical receptor structure.
Pierre De Meyts, Brenda Wallach, Claus T. Christoffersen, Birgitte Ursø, Karen Grønskov, Lori-Jo Latus, Fumiatsu Yakushiji, Mapoko Ilondo, Ronald M. Shymko   +8 more
openaire   +1 more source

Insulin-like growth factor receptors and binding proteins

Baillière's Clinical Endocrinology and Metabolism, 1996
The insulin-like growth factor receptors are integral membrane proteins and demonstrate separate, but important effects on the regulation of cellular processes. The IGF-I receptor signals multiple cascades via its inherent tyrosine kinase activity. The IGF-II/M-6-P receptor on the other hand is primarily involved in targeting of enzymes to various ...
openaire   +2 more sources

Intracellular Transactivation of the Insulin-like Growth Factor I Receptor by an Epidermal Growth Factor Receptor

Experimental Cell Research, 1996
Growth factor receptors may be transactivated not only by homologous receptors, but also by heterologous receptors. We have investigated this possibility, using for this purpose R-/EGFR cells, which are mouse embryo cells devoid of IGF-I receptors, but overexpressing the EGF receptor. At variance with mouse embryo cells with a wild-type number of IGF-I
J L, Burgaud, R, Baserga
openaire   +2 more sources

Insulin-Like Growth Factor Receptors in the Brain

1987
A growing body of evidence now indicates that the central nervous system (CNS) is a target of peptides from the gut and pancreas. Insulin from the pancreatic islets, for example, enters the brain from the periphery and influences the physiology of the CNS (review by Baskin et al., 1987). The recent appreciation that insulin-like growth factors (IGF’s),
Denis G. Baskin, Nancy J. Bohannon, Dianne P. Figlewicz   +2 more
openaire   +1 more source

Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland

Journal of Dairy Research, 1999
The mammary gland is an example of a tissue of epidermal origin that depends for the development of its characteristic morphology on underlying mesenchymal cells. The interaction between mesenchyme and epithelium appears to be mediated by polypetide growth factors.
Forsyth, Isabel A., Gabai, Gianfranco, Morgan, Geoff   +2 more
openaire   +4 more sources

Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.

International Journal of Molecular Medicine, 1998
Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this ...
Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A   +5 more
openaire   +4 more sources

Insulin-Like Growth Factor-II Receptors

1990
In the past few years there has been an explosive increase in interest in peptides of the insulin-like growth factor (IGF) family. This follows a period of over two decades, dating back to the discovery of “somatomedins,” as the IGFs were originally known, in the late 1950s.
Robert C. Baxter, Carolyn D. Scott
openaire   +1 more source

Insulin‐like growth factor I receptors and insulin‐like growth factor‐binding proteins in human parathyroid tumors

World Journal of Surgery, 1994
AbstractStudies have demonstrated the presence of epidermal growth factor receptors in human parathyroid tumors. However, there is little information on the effect of other peptide growth factors on parathyroid cell growth. We therefore studied the interaction of insulin‐like growth factor I (IGF‐I) with human parathyroid tumor cells.
R, Tanaka, T, Tsushima, H, Murakami, K, Shizume, T, Obara   +4 more
openaire   +2 more sources