Results 91 to 100 of about 815 (149)

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

, 2017
Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation into the brain, reduced in vivo brain glucose uptake, GLUT4 expression,
Laura Mateos, Zeina Ali, Irina Savitcheva, Eric Westman, Muhammad-Al-Mustafa Ismail, Paula Merino-Serrais, Angel Cedazo-Mínguez, Maria Lodeiro, Eran Leitersdorf, Ingemar Björkhem, Balázs Gulyás, Lars Olof-Wahlund, Silvia Maioli, Bengt Winblad   +13 more
core   +1 more source

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

, 2015
Transition state- and high energy intermediate mimetics have the potential to be very potent enzyme inhibitors. In this study a model of peptide hydrolysis in the active site of insulin-regulated aminopeptidase (IRAP) was developed using density ...
Skold, C, Svensson, Fredrik,, Lundbäck, Thomas,, Engen, Karin,, Larhed, Mats,, Fredrik Svensson, Sköld, Christian,, Larhed, M, Engen, K, Karin Engen, Lundback, T, Mats Larhed, Thomas Lundbäck, Christian Sköld, Svensson, F   +14 more
core   +1 more source

Optimization and structure-activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides

, 2016
The oxytocinase subfamily of M1 aminopeptidases, consisting of ER aminopeptidase 1 (ERAP1), ER aminopeptidase 2 (ERAP2), and insulin-regulated aminopeptidase (IRAP), plays critical roles in the generation of antigenic peptides and indirectly regulates ...
Efstratios Stratikos (340662), Petropoulou, Ioanna, Paraskevi Kokkala (3127509), Georgiadis, Dimitris, Athanasios Papakyriakou (375921), Dimitris Georgiadis (2325748), Mirto Papathanasopoulou (3127518), Stefanos Agrotis (3127527), Sofia Kavvalou (3127512), Papathanasopoulou, Mirto, Daskalaki, Ira, Van Endert, Peter, Fonsou, Theodora Markisia, Kavvalou, Sofia, Kokkala, Paraskevi, Anastasia Mpakali (3127524), Agrotis, Stefanos, Ira Daskalaki (3127530), Papakyriakou, Athanasios, Stratikos, Efstratios, Peter van Endert (49012), Theodora-Markisia Fonsou (3127521), Mpakali, Anastasia, Francois-Xavier Mauvais (1656322), Mauvais, Francois Xavier, Ioanna Petropoulou (3127515)   +25 more
core   +1 more source

Angiotensin IV binding site - The AT4 receptor or insulin regulated aminopeptidase (IRAP)

, 2007
Angiotensin IV (Ang IV) is a hexapeptide fragment corresponding to amino acids 3-8 (VYIHPF) of angiotensin II (Ang II) that is formed by consecutive actions of aminopeptidase A and aminopeptidase N (1) (Fig. 1).
S CHAI (19974987), F Mendelsohn (13733029), Trisha Jenkins (18031216), Anthony Albiston (19974984)   +3 more
core   +1 more source

Conformational Changes in Insulin Regulated Aminopeptidase

, 2021
Global disease burden due to age related cognitive decline and dementias, especially Alzheimer’s disease, are a growing public health problem. Current treatments fail to completely prevent or cure dementia.
Moes, Sebastian
core  

Angiotensin receptors: form and function and distribution

, 2003
The peptide hormone, angiotensin II, acts primarily via type I (AT1) and type II (AT2) angiotensin receptors. Proteolytic fragments of angiotensin II also have biological activity via these and other receptors, with actions that may mimic or antagonise ...
Thomas, Walter G., Mendelsohn, Frederick A. O.   +1 more
core   +1 more source

Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity

, 2017
Insulin-regulated aminopeptidase (IRAP) is an enzyme with several important biological functions that is known to process a large variety of different peptidic substrates although the mechanism behind this wide specificity is not clearly understood.
Giastas, P, Kokkala, P, Georgiadis, Dimitris, Anastasia Mpakali, Georgiadis, D, Karl Harlos, Zhao, Y, Mpakali, A, Giastas, Petros, Paraskevi Kokkala, Harlos, Karl, Yuguang Zhao, Dimitris Georgiadis, Emmanuel Saridakis, Kokkala, Paraskevi, Athanasios Papakyriakou, Petros Giastas, Papakyriakou, Athanasios, Stratikos, Efstratios, Papakyriakou, A, Harlos, K, Saridakis, E, Efstratios Stratikos, Zhao, Yuguang, Mpakali, Anastasia, Saridakis, Emmanuel, Stratikos, E   +26 more
core   +2 more sources

Endoplasmic reticulum aminopeptidase 1 (ERAP1; ARTS1; ERAAP); ERAP2; insulin-regulated aminopeptidase (IRAP) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Does IRAP contribute to Alzheimer's Disease Pathology?

Alzheimer’s disease is a progressive brain disease which is results in memory loss and cell death. All currently prescribed drugs treat the memory loss but are unable to stop the deterioration of brain cells.

core  

Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress. [PDF]

Am J Physiol Renal Physiol, 2023
Zuchowski Y, Carty J, Terker AS, Bock F, Trapani JB, Bhave G, Watts JA, Keller S, Zhang M, Zent R, Harris RC, Arroyo JP.   +11 more
europepmc   +1 more source