Results 81 to 90 of about 815 (149)

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

, 2003
Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 receptor has recently been identified as the insulin-regulated aminopeptidase (IRAP).
Siying Ye (13094898), R Lew (13471534), S Chai (9882683), T Mustafa (13733881), S McDowall (13733884), A Albiston (13732981)   +5 more
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Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

, 2016
A fast and convenient synthetic route towards spiro-oxindole dihydroquinazolinones as novel and drug-like insulin-regulated aminopeptidase (IRAP) inhibitors is reported. The synthesis is performed using a MW heated continuous flow system employing 200 mm
Annika Jenmalm-Jensen (1717414), Mats Larhed (492164), Ulrika Rosenström (1717417), Thomas Lundbäck (1399552), Johan Wannberg (1450513), Jonas Sävmarker (1285632), Karin Engen (1346442)   +6 more
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Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Methatesis

, 2011
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Demaegdt, H, Karlén, Anders, Erdelyi, Mate,, Lindeberg, G, Hallberg, Anders, Andersson, Hanna, ´Vaquelin, G, Hallberg, Matthias, Johansson, Anja   +8 more
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Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures

, 2015
Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where it modulates neuronal activity.
De Bundel, Dimitri, Auvin, S, Dournard, P, Thermos, Kyriaki, Coppens, J, Smolders, I, El Ghouzzi, V., Vodjdani, G, Aourz, N., Gressens, P., Bernard, Véronique, El Ghouzzi, V, Csaba, Zsolt, Chai, SY, Gressens, P, Portelli, J., Bernard, V., Fafouri, Assia, Chai, Siew Yeen, Loyens, E., Csaba, Z., Aourz, N, Thermos, K, Lovens, E, Vanderheyden, Patrick, De Bundel, D, Lebon, Sophie, Smolders, I., Loyens, Ellen, Dournaud, P., El Ghouzzi, Vincent, Peineau, S, Peineau, Stéphane, Casaba, Z, Chai, S., Coppens, Jessica, Vanderheyden, P., De Bundel, D., Kiagiadaki, F., Auvin, S., Collingridge, Graham, Collingridge, G., Vodjdani, Guilan, Bernard, V, Walrave, Laura, Walrave, L., Auvin, Stéphane, Lebon, S., Portelli, Jeanelle, Aourz, Najat, Walrave, L, Vanderheyden, P, Dournaud, Pascal, Thermos, K., Fafouri, A., Fafouri, A, Peineau, S., Coppens, J., Gressens, Pierre, Lebon, S, Vodjdani, G., Smolders, Ilse, Kiagiadaki, F, Kiagiadaki, Foteini   +63 more
core   +2 more sources

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase [PDF]

, 2008
The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss.
Ascher, DB, Hayley T Mulvey, Parker, MW, Anthony L Albiston, Siew Chai, David B Ascher, Mulvey, HT, Michael W Parker, Thompson, PE, Albiston, AL, Yeatman, HR, Philip E Thompson, Chai, SY, Holly R Yeatman   +13 more
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Cellular characterisation of the insulin-regulated aminopeptidase (IRAP) in the brain

, 2006
TypescriptThesis (PhD) -- University of Melbourne, Dept. of Genetics, Howard Florey Institute, 2006Includes bibliographical references (leaves 182-201)Central infusions of AT4 ligands, including Angiotensin IV and LW-Hemorphin 7, enhance memory ...
Fernando, Ruani Natashia.
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Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

, 2020
Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target.
Giastas, Petros, Giastas, Petros,, Hallberg, Mathias,, Larhed, Mats,, Maben, Zachary,, Mpakali, Anastasia,, Stratikos, Efstratios, Stratikos, Efstratios,, Stern, Lawrence J., Mpakali, Anastasia, Saridakis, Emmanuel, Maben, Zachary, Larhed, Mats, Stern, Lawrence J.,, Hallberg, Mathias, Saridakis, Emmanuel,   +15 more
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Molecular characterization of insulin-regulated aminopeptidase (IRAP)

, 2006
© 2006 Dr. Siying YeCentral infusion of the hexapeptide angiotensin IV (Ang IV) and its analogs have been demonstrated to markedly enhance memory retention and retrieval in rats using a range of learning and memory paradigms.
Ye, Siying
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IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

, 2009
Major histocompatibility complex (MHC) class I molecules present peptides, produced through cytosolic proteasomal degradation of cellular proteins, to cytotoxic T lymphocytes.
Carroll, Oliver, Weimershaus, Mirjana, van Endert, Peter, Weimershaus, M., Lindo, V., Davoust, Jean, Firat, Elke, Guermonprez, P., Greer, F., Firat, E., Kratzer, R., Keller, S. R., Greer, Fiona, Niedermann, G., van Endert, P., Saveanu, L., Guermonprez, Pierre, Niedermann, Gabriele, Davoust, J., Carroll, O., Keller, Susanna R., Saveanu, Loredana, Lindo, Vivian, Kratzer, Roland   +23 more
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Involvement of the somatostatin 2 receptor in the anticonvulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats

, 2006
The anti-convulsant properties of angiotensin IV (Ang IV), an inhibitor of insulin-regulated aminopeptidase (IRAP) and somatostatin-14, a substrate of IRAP, were evaluated in the acute pilocarpine rat seizure model.
De Bundel, Dimitri, Ebinger, Guy, Stragier, B, Smolders, I, Stragier, Bart, Clinckers, R, Ebinger, G, Sarre, S, Smolders, Ilse, Clinckers, Ralph, Meurs, Alfred, De Bundel, D, Michotte, Yvette, Michotte, Y, Sarre, Sophie   +14 more
core   +1 more source