Results 61 to 70 of about 815 (149)
Frontiers in Molecular Biosciences, 2020 Insulin-regulated aminopeptidase (IRAP, cystinyl aminopeptidase, CysAP) and aminopeptidase M (alanyl aminopeptidase, AlaAP) are closely related enzymes involved in cognitive, metabolic, and cardiovascular functions.
Ana Belén Segarra +7 more
doaj +1 more source
PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease
MedComm, Volume 6, Issue 9, September 2025.PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei +9 more
wiley +1 more source
Journal of Diabetes Research, Volume 2019, Issue 1, 2019., 2019 Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood. Kynurenic acid (KYNA), endogenous kynurenine metabolite, displays pleiotropic effects, including a blockade of glutamatergic and cholinergic receptors.
Iwona Chmiel-Perzyńska +6 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 8, August 2025.The role of the Classical and Non‐Classical RAS pathway in Parkinson's disease: Pathogenesis and Therapeutic strategies. PD, Parkinson's disease; DNs, Dopaminergic neurons; SN, Substantia Nigra; α‐syn, alpha‐synuclein; RAS, renin‐angiotensin system; Ang II, Angiotensin II; AT1R, Angiotensin II type 1 Receptor; ACE2, angiotensin‐converting enzyme 2; Ang
Ghadah H. Alshehri +7 more
wiley +1 more source
Dandelion Chloroform Extract Promotes Glucose Uptake via the AMPK/GLUT4 Pathway in L6 Cells
Evidence-Based Complementary and Alternative Medicine, Volume 2018, Issue 1, 2018., 2018 The number of patients with type 2 diabetes mellitus (T2DM) is increasing rapidly worldwide. Glucose transporter 4 (GLUT4) is one of the main proteins that transport blood glucose into the cells and is a target in the treatment of T2DM. In this study, we investigated the mechanism of action of dandelion chloroform extract (DCE) on glucose uptake in L6 ...
Ping Zhao +12 more
wiley +1 more source
مجله كليه طب الكنديBackground: Different proposed mechanisms for insulin resistance have been put forth to understand the relationship and changes in insulin resistance. Looking at the levels of insulin, the neurotransmitter gamma-aminobutyric acid, glucose transport type
Ismael Sadeq Khashan +1 more
doaj +1 more source
Novel selective inhibitors of aminopeptidases that generate antigenic peptides [PDF]
, 2013 Endoplasmic reticulum aminopeptidases, ERAP1 and ERAP2, as well as Insulin regulated aminopeptidase (IRAP) play key roles in antigen processing, and have recently emerged as biologically important targets for manipulation of antigen presentation.
Papakyriakou, Athanasios +5 more
core +1 more source
International Journal of Endocrinology, Volume 2018, Issue 1, 2018., 2018 Ischemia‐reperfusion (I/R) injury is a well‐known phenomenon that involves different pathophysiological processes. Connection in diverse systems of survival brings about cellular dysfunction or even apoptosis. One of the survival systems of the cells, to the assault caused by ischemia, is the activation of the renin‐angiotensin‐aldosterone system (also
Simón Quetzalcóatl Rodríguez-Lara +3 more
wiley +1 more source
Targeting IRAP as a novel strategy to reduce renal fibrosis and injury in chronic kidney disease
, 2023 New strategies are needed to combat pathological organ fibrosis, leading to end stage organ failure. We have identified the enzyme insulin regulated aminopeptidase (IRAP), as one such promising new target.
SHARENYA CHELVARETNAM (17421612)
core +1 more source
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation [PDF]
International Journal of Molecular SciencesKarin Engen +2 more
exaly +2 more sources